Health (PRISME)
- Presentation
- Activities
- Members
- Publications
The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.
Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.
One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.
The activities can be divided into three research areas:
Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.
Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.
Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.
NON-PERMANENTS:
- DOCTORANTS / DOCTORAL STUDENTS:
- V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for exotic decays of a Higgs boson into undetectable particles and photons. Physics Letters B, 2016, 753, pp.363-388. ⟨10.1016/j.physletb.2015.12.017⟩. ⟨in2p3-01171155⟩
- V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of the inelastic cross section in proton-lead collisions at a centre-of-mass energy per nucleon pair of 5.02 TeV. Physics Letters B, 2016, 759, pp.641-662. ⟨10.1016/j.physletb.2016.063.027⟩. ⟨in2p3-01199146⟩
- V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for neutral MSSM Higgs bosons decaying to
in pp collisions at 
7 and 8 TeV. Physics Letters B, 2016, 752, pp.221-246. ⟨10.1016/j.physletb.2015.11.042⟩. ⟨in2p3-01186123⟩ - V.M. Abazov, U. Bassler, G. Bernardi, M. Besançon, D. Brown, et al.. Evidence for simultaneous production of
and 
mesons. Physical Review Letters, 2016, 116, pp.082002 ⟨10.1103/PhysRevLett.116.082002⟩. ⟨in2p3-01226717⟩ - Yi Cao, J. Johansson, Peter E. Nugent, A. Goobar, Jakob Nordin, et al.. An Intermediate Type Ia Supernova Between Normal And Super-Chandrasekhar. The Astrophysical Journal, 2016, 823, pp.147. ⟨10.3847/0004-637X/823/2/147⟩. ⟨in2p3-01338216⟩
- Benoîte Méry, Jean-Baptiste Guy, Sophie Espenel, Anne-Sophie Wozny, Stéphanie Simonet, et al.. Targeting head and neck tumoral stem cells: From biological aspects to therapeutic perspectives. World Journal of Stem Cells, 2016, 8 (1), pp.13-21. ⟨10.4252/wjsc.v8.i1.13⟩. ⟨hal-01277977⟩
- Benoîte Méry, Chloé Rancoule, Jean-Baptiste Guy, Sophie Espenel, Anne-Sophie Wozny, et al.. Cellules souches tumorales : aspects radiothérapeutiques et ciblage thérapeutique. Bulletin du Cancer, 2016, 103 (1), pp.48-54. ⟨10.1016/j.bulcan.2015.10.018⟩. ⟨hal-01277999⟩
- J. Vijande, A. Valcarce, J. -M. Richard, P. Sorba. Search for doubly-heavy dibaryons in a quark model. Physical Review D, 2016, 94, pp.034038. ⟨10.1103/PhysRevD.94.034038⟩. ⟨in2p3-01358179⟩
- G. Cacciapaglia, A. Deandrea, S. Gascon, S. Le Corre, M. Lethuillier, et al.. Search for a lighter Higgs in Two Higgs Doublet Models. Journal of High Energy Physics, 2016, 068, ⟨10.1007/JHEP12(2016)068⟩. ⟨in2p3-01358182⟩
- M. V. Diwan, V. Galymov, X. Qian, A. Rubbia. Long-Baseline Neutrino Experiments. Annual review of nuclear science, 2016, 66, pp.47-71. ⟨10.1146/annurev-nucl-102014-021939⟩. ⟨in2p3-01358176⟩
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