Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8787 documents

  • V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for a Higgs boson decaying into gamma* gamma to ll gamma with low dilepton mass in pp collisions at sqrt(s) = 8 TeV. Physics Letters B, 2016, 753, pp.341-362. ⟨10.1016/j.physletb.2015.12.039⟩. ⟨in2p3-01279443⟩
  • J. Adam, Laurent Aphecetche, A. Baldisseri, Guillaume Batigne, I. Belikov, et al.. Pseudorapidity and transverse-momentum distributions of charged particles in proton-proton collisions at \mathbf{\sqrt{\textit s}} = 13 TeV. Physics Letters B, 2016, 753, pp.319-329. ⟨10.1016/j.physletb.2015.12.030⟩. ⟨in2p3-01207015⟩
  • J. Adam, Laurent Aphecetche, A. Baldisseri, Guillaume Batigne, I. Belikov, et al.. Centrality evolution of the charged-particle pseudorapidity density over a broad pseudorapidity range in Pb-Pb collisions at \sqrt{s_{\rm NN}} = 2.76 TeV. Physics Letters B, 2016, 754, pp.373-385. ⟨10.1016/j.physletb.2015.12.082⟩. ⟨in2p3-01205165⟩
  • E. Armengaud, Q. Arnaud, C. Augier, A. Benoît, L. Bergé, et al.. Constraints on low-mass WIMPs from the EDELWEISS-III dark matter search. Journal of Cosmology and Astroparticle Physics, 2016, 05, pp.019. ⟨10.1088/1475-7516/2016/05/019⟩. ⟨in2p3-01289579⟩
  • J. Adam, Laurent Aphecetche, B. Audurier, A. Baldisseri, Guillaume Batigne, et al.. Multiplicity dependence of charged pion, kaon, and (anti)proton production at large transverse momentum in p-Pb collisions at \mathbf{\sqrt{{\textit s}_{\rm NN}}} = 5.02 TeV. Physics Letters B, 2016, 760, pp.720-735. ⟨10.1016/j.physletb.2016.07.050⟩. ⟨in2p3-01256539⟩
  • Sergey Alekhin, Wolfgang Altmannshofer, Takehiko Asaka, Brian Batell, Fedor Bezrukov, et al.. A facility to Search for Hidden Particles at the CERN SPS: the SHiP physics case. Reports on Progress in Physics, 2016, 79, pp.124201. ⟨10.1088/0034-4885/79/12/124201⟩. ⟨in2p3-01148638⟩
  • J. Adam, G. Conesa Balbastre, J. Faivre, C. Furget, R. Guernane, et al.. Forward-central two-particle correlations in p-Pb collisions at \sqrt{s_{\rm NN}} = 5.02 TeV. Physics Letters B, 2016, 753, pp.126-139. ⟨10.1016/j.physletb.2015.12.010⟩. ⟨in2p3-01172182⟩
  • E. Carlesi, Y. Hoffman, J.G. Sorce, S. Gottlöber, G. Yepes, et al.. The tangential velocity of M31: CLUES from constrained simulations. Monthly Notice- Royal Astronomical Society -Letters-, 2016, 460 (1), pp.L5-L9. ⟨10.1093/mnrasl/slw059⟩. ⟨in2p3-01367383⟩
  • J. Kopyra, H. Abdoul-Carime. Unusual temperature dependence of the dissociative electron attachment cross section of 2-thiouracil. The Journal of Chemical Physics, 2016, 144, pp.034306. ⟨10.1063/1.4940147⟩. ⟨in2p3-01271620⟩
  • J.-M. Richard. Exotic hadrons: review and perspectives. Few-Body Systems, 2016, 57 (12), pp.1185-1212. ⟨10.1007/s00601-016-1159-0⟩. ⟨in2p3-01338649⟩

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