Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • D. Tsimpis, Y. Zhu. \mathcal{N}=1 Chern-Simons-matter theory and localization. Nuclear Physics B, 2016, 911, pp.355 - 387. ⟨10.1016/j.nuclphysb.2016.08.013⟩. ⟨in2p3-01302362⟩
    • J. Adam, Laurent Aphecetche, A. Baldisseri, Guillaume Batigne, I. Belikov, et al.. Multiplicity and transverse momentum evolution of charge-dependent correlations in pp, p-Pb, and Pb-Pb collisions at the LHC. European Physical Journal C: Particles and Fields, 2016, 76, pp.86. ⟨10.1140/epjc/s10052-016-3915-1⟩. ⟨in2p3-01205163⟩
    • D.B. Franzosi, G. Cacciapaglia, H. Cai, A. Deandrea, M. Frandsen. Vector and Axial-vector resonances in composite models of the Higgs boson. Journal of High Energy Physics, 2016, 1611, pp.076. ⟨10.1007/JHEP11(2016)076⟩. ⟨in2p3-01314252⟩
    • Chloé Rancoule, Nicolas Magné, Alexis Vallard, Jean-Baptiste Guy, Claire Rodriguez-Lafrasse, et al.. Nanoparticles in radiation oncology: From bench-side to bedside. Cancer Letters, 2016, 375 (2), pp.256-262. ⟨10.1016/j.canlet.2016.03.011⟩. ⟨hal-01376249⟩
    • N. Moncoffre, N. Toulhoat, N. Bérerd, Y. Pipon, G. Silbermann, et al.. Impact of radiolysis and radiolytic corrosion on the release of ^{13}C and ^{37}Cl implanted into nuclear graphite: Consequences for the behaviour of ^{14}C and ^{36}Cl in gas cooled graphite moderated reactors. Journal of Nuclear Materials, 2016, 472, pp.252-258. ⟨10.1016/j.jnucmat.2015.12.020⟩. ⟨in2p3-01295487⟩
    • V.M. Abazov, U. Bassler, M. Besançon, E. Chapon, F. Couderc, et al.. Measurement of the forward-backward asymmetries in the production of \Xi and \Omega baryons in p \bar{p} collisions. Physical Review D, 2016, 93, pp.112001. ⟨10.1103/PhysRevD.93.112001⟩. ⟨in2p3-01314763⟩
    • J. Adam, Laurent Aphecetche, B. Audurier, A. Baldisseri, Guillaume Batigne, et al.. Differential studies of inclusive J/\psi and \psi(2S) production at forward rapidity in Pb-Pb collisions at \mathbf{\sqrt{{\textit s}_{_{NN}}}} = 2.76 TeV. Journal of High Energy Physics, 2016, 05(2016), pp.179. ⟨10.1007/JHEP05(2016)179⟩. ⟨in2p3-01169681⟩
    • R. Jodon, M. Bender, K. Bennaceur, J. Meyer. Constraining the surface properties of effective Skyrme interactions. Physical Review C, 2016, 94, pp.024335. ⟨10.1103/PhysRevC.94.024335⟩. ⟨in2p3-01328000⟩
    • J.G. Sorce, S. Gottloeber, G. Yepes, Y. Hoffman, H.M. Courtois, et al.. Cosmicflows Constrained Local UniversE Simulations. Monthly Notices of the Royal Astronomical Society, 2016, 455, pp.2078-2090. ⟨10.1093/mnras/stv2407⟩. ⟨in2p3-01219773⟩
    • J. Adam, Laurent Aphecetche, B. Audurier, A. Baldisseri, Guillaume Batigne, et al.. Higher harmonic flow coefficients of identified hadrons in Pb-Pb collisions at \sqrt{s_{\rm NN}} = 2.76 TeV. Journal of High Energy Physics, 2016, 09, pp.164. ⟨10.1007/JHEP09(2016)164⟩. ⟨in2p3-01334579⟩

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