Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • J. Adam, Laurent Aphecetche, B. Audurier, A. Baldisseri, Guillaume Batigne, et al.. Multiplicity dependence of charged pion, kaon, and (anti)proton production at large transverse momentum in p-Pb collisions at \mathbf{\sqrt{{\textit s}_{\rm NN}}} = 5.02 TeV. Physics Letters B, 2016, 760, pp.720-735. ⟨10.1016/j.physletb.2016.07.050⟩. ⟨in2p3-01256539⟩
  • J. Adam, G. Conesa Balbastre, J. Faivre, C. Furget, R. Guernane, et al.. Forward-central two-particle correlations in p-Pb collisions at \sqrt{s_{\rm NN}} = 5.02 TeV. Physics Letters B, 2016, 753, pp.126-139. ⟨10.1016/j.physletb.2015.12.010⟩. ⟨in2p3-01172182⟩
  • J. Adam, Laurent Aphecetche, A. Baldisseri, Guillaume Batigne, I. Belikov, et al.. Centrality evolution of the charged-particle pseudorapidity density over a broad pseudorapidity range in Pb-Pb collisions at \sqrt{s_{\rm NN}} = 2.76 TeV. Physics Letters B, 2016, 754, pp.373-385. ⟨10.1016/j.physletb.2015.12.082⟩. ⟨in2p3-01205165⟩
  • J. Adam, Laurent Aphecetche, A. Baldisseri, Guillaume Batigne, I. Belikov, et al.. Pseudorapidity and transverse-momentum distributions of charged particles in proton-proton collisions at \mathbf{\sqrt{\textit s}} = 13 TeV. Physics Letters B, 2016, 753, pp.319-329. ⟨10.1016/j.physletb.2015.12.030⟩. ⟨in2p3-01207015⟩
  • J. Adam, R. Vernet, I. Belikov, B. Hippolyte, C. Kuhn, et al.. Elliptic flow of muons from heavy-flavour hadron decays at forward rapidity in Pb-Pb collisions at \sqrt{s_{\rm NN}}=2.76 TeV. Physics Letters B, 2016, 753, pp.41-56. ⟨10.1016/j.physletb.2015.11.059⟩. ⟨in2p3-01279455⟩
  • R. Jodon, M. Bender, K. Bennaceur, J. Meyer. Constraining the surface properties of effective Skyrme interactions. Physical Review C, 2016, 94, pp.024335. ⟨10.1103/PhysRevC.94.024335⟩. ⟨in2p3-01328000⟩
  • A. Falkowski, M. Gonzalez-Alonso, Admir Greljo, David Marzocca. Global Constraints on Anomalous Triple Gauge Couplings in the Effective Field Theory Approach. Physical Review Letters, 2016, 116, pp.011801. ⟨10.1103/PhysRevLett.116.011801⟩. ⟨in2p3-01192639⟩
  • A. Andronic, F. Arleo, R. Arnaldi, A. Beraudo, E. Bruna, et al.. Heavy-flavour and quarkonium production in the LHC era: from proton-proton to heavy-ion collisions. European Physical Journal C: Particles and Fields, 2016, 76, pp.107. ⟨10.1140/epjc/s10052-015-3819-5⟩. ⟨in2p3-01169535⟩
  • T. Price, N. K. Watson, J. S. Marshall, M. A. Thomson, D. R. Ward, et al.. Hadron shower decomposition in the highly granular CALICE analogue hadron calorimeter. Journal of Instrumentation, 2016, 11, pp.P06013. ⟨10.1088/1748-0221/11/06/P06013⟩. ⟨in2p3-01281362⟩
  • N. Moncoffre, N. Toulhoat, N. Bérerd, Y. Pipon, G. Silbermann, et al.. Impact of radiolysis and radiolytic corrosion on the release of ^{13}C and ^{37}Cl implanted into nuclear graphite: Consequences for the behaviour of ^{14}C and ^{36}Cl in gas cooled graphite moderated reactors. Journal of Nuclear Materials, 2016, 472, pp.252-258. ⟨10.1016/j.jnucmat.2015.12.020⟩. ⟨in2p3-01295487⟩

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