Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:
    545 documents

    • Jean-Baptiste Guy, Sophie Espenel, Safa Louati, Alexis Vallard, Anne‐sophie Wozny, et al.. Synergic effect of cetuximab and ABT-199 combined with radiation in head and neck squamous cell carcinoma. ICRR 2019, Aug 2019, Manchester, United Kingdom. ⟨hal-02358905⟩
    • Floriane Poignant, Benoit Gervais, Andrei Ipatov, Caterina Monini, Etienne Testa, et al.. Physical, chemical and biological modelling of the radiosensitizing effect of high-Z nanoparticles. ICRR 2019, Aug 2019, Manchester, United Kingdom. ⟨hal-02355457⟩
    • C. Rodriguez-Lafrasse, M.-T. Aloy, G. Ollier, Delphine Vernos, Riad Ladjohounlou, et al.. Transfer of the ultrasmall theranostic gadolinium-based nanoparticle AGuIX® to clinical medicine. ICRR 2019, Aug 2019, Manchester, United Kingdom. ⟨hal-04998562⟩
    • Caterina Monini, Gersende Alphonse, Claire Rodriguez-Lafrasse, Etienne Testa, Michael Beuve. NanOx’s predictions of cell survival probability for three cell lines, and study of the influence of its parameters. ICRR 2019, Aug 2019, Manchester, United Kingdom. ⟨hal-02355520⟩
    • S. Curtoni, G. Bosson, J. Bouvier, J. Collot, D. Dauvergne, et al.. Towards a beam-tagging diamond hodoscope for online ion range monitoring. ENLIGHT 2019 : annual meeting of the European Network for Light Ion Hadron Therapy, Jul 2019, Caen, France. ⟨hal-02351809⟩
    • M. Beuve. NanOx, a new multiscale model to predict biological effects of ionizing radiation. European Network for Light Ion Hadron Therapy (ENLIGHT) annual meeting, Jul 2019, Caen, France. ⟨hal-02355745⟩
    • Anne-Sophie Wozny, Guillaume Varès, Gersende Alphonse, Caterina Monini, Philippe Lalle, et al.. A Paradigm to Explain the Differential Effects of X-ray and Carbon Ion Irradiation on tumor cells. 17th European Network for Light Ion Hadron Therapy (ENLIGHT 2019), Jul 2019, Caen, France. ⟨hal-02355841⟩
    • Yasmine Ali, Caterina Monini, Jean Michel Létang, Etienne Testa, Lydia Maigne, et al.. Simulation of micro- nanodosimetry spectra and free radicals with Geant4-DNA, LQD, PHYCHEML, CHEM for ion beams. ICCR-MCMA The International Conference on the Use of Computers in Radiation Therapy and the International Conference on Monte Carlo Techniques for Medical Applications, Jun 2019, Montreal, Canada. ⟨hal-02308706⟩
    • Y. Ali, C. Monini, J.M. Létang, E. Testa, L. Maigne, et al.. Simulation of micro-nanodosimetry spectra and free radicals with Geant4-DNA, LQD,PHYSCHEML,CHEM for ion beams. ICCR-MCMA - the international conference on the use of computers in radiation therapy and the international conference on Monte-Carlo techniques for medical applications, Jun 2019, Online, France. ⟨in2p3-04954695⟩
    • Nils Krah, Jean Michel Létang, Simon Rit. An analytical method to sample proton trajectories under the influence of multiple Coulomb scattering. International Conference on the Use of Computers in Radiation Therapy (ICCR), Jun 2019, Montreal, Canada. ⟨hal-02283827⟩

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