Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:
    540 documents

    • Hamid Ladjal, Michaël Beuve, Shariat Behzad. Patient-Specific Biomechanical Diaphragm-Ribs Respiratory Motion Model for Radiation Therapy. IEEE Transactions on Medical Robotics and Bionics, 2025, 7 (2), pp.802-813. ⟨10.1109/TMRB.2025.3560383⟩. ⟨hal-04999920⟩
    • Janina Kopyra, Aleksandr Bancer, Hassan Abdoul-Carime. Low energy electron induced fragmentation of hot asparagine and aspartic acid molecules. J.Chem.Phys., 2025, 162 (17), pp.174305. ⟨10.1063/5.0254082⟩. ⟨hal-05059790⟩
    • Hassan Abdoul-Carime, Janina Kopyra. Synthesis of Resorcinol and Chlorophenol from Irradiation of 1,3-Dichlorobenzene in a Water Ice Environment by Low-Energy Electrons. International Journal of Molecular Sciences, 2025, 26 (2), pp.688. ⟨10.3390/ijms26020688⟩. ⟨hal-04906250⟩
    • Mario Alcocer‐ávila, Étienne Testa, Michaël Beuve. Analytical expression of the β\beta coefficient of cell survival curves predicted by the NanOx model in the low‐energy range. Medical Physics : The international journal of medical physics research and practice, 2025, 52 (10), pp.e70008. ⟨10.1002/mp.70008⟩. ⟨hal-05294368⟩
    • Hassan Abdoul-Carime, Louisa Castel, Franck Rabilloud. Insights into the C-Cl Bond Breaking in Epichlorohydrin Induced by Low Energy (<10 eV) Electrons. Molecules, 2024, 29 (24), pp.6051. ⟨10.3390/molecules29246051⟩. ⟨hal-04855194⟩
    • G. Alphone, S. Malesys, C. Bovio, H. Ladjal, A.-S. Wozny, et al.. Caractérisation de la mécanique cellulaire par microscopie AFM comme biomarqueur du potentiel métastatique des cellules tumorales. 2ème Congrès de Radiobiologie de la SFBR, Oct 2024, Porquerolles (Hyères), France. ⟨in2p3-04956182⟩
    • M. Tissot, G. Alphonse, C. Melsys, V. Varoclier, C. Belleron, et al.. Etude de l’impact de l’irradiation photonique ou par ions carbone sur la protéostase. 2ème Congrès de Radiobiologie de la SFBR, Oct 2024, Porquerolles (Hyères), France. ⟨in2p3-04956195⟩
    • Mario Alcocer-Ávila, Victor Levrague, Thomas Berger, María Pedrosa-Rivera, Anthony Bertrand, et al.. Update on the NanOx biophysical model: Current status and perspectives. Assemblée Générale 2024 du GdR Mi2B, Oct 2024, Grenoble, France. ⟨in2p3-04954446⟩
    • Hassan Abdoul-Carime, Guillaume Thiam, Franck Rabilloud. Production of Nitrogen Dioxide, NO2 – , Anion from Dissociative Electron Attachment to Nitromethane below 1 eV and Its Temperature Dependence: Direct vs Dipole Bound Mediated Processes. Journal of Physical Chemistry Letters, 2024, 15 (41), pp.10329-10333. ⟨10.1021/acs.jpclett.4c02602⟩. ⟨hal-04753094⟩
    • C. Rodriguez-Lafrasse. CuPRIX a new generation of AGuIX therapeutic nanoparticles combines tumor sensitization to irradiation and copper depletion to overcom radioresistant and metastatic cancers. 70th Annual Meeting of the Radiation Research Society, Sep 2024, Tucson (AZ), United States. ⟨in2p3-04955997⟩

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