Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • K. Abe, D. Autiero, S. Bolognesi, M. Buizza Avanzini, O. Drapier, et al.. Measurement of muon anti-neutrino oscillations with an accelerator-produced off-axis beam. Physical Review Letters, 2016, 116, pp.181801. ⟨10.1103/PhysRevLett.116.181801⟩. ⟨in2p3-01240290⟩
  • Marion Gilormini, Anne-Sophie Wozny, Priscillia Battiston-Montagne, Dominique Ardail, Gersende Alphonse, et al.. Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics. Journal of visualized experiments : JoVE, 2016, pp.e53958. ⟨10.3791/53958⟩. ⟨hal-01277890⟩
  • Marion Gilormini, Céline Malésys, Emma Armandy, Patrick Manas, Jean-Baptiste Guy, et al.. Preferential targeting of cancer stem cells in the radiosensitizing effect of ABT-737 on HNSCC. Oncotarget, 2016, 7 (13), pp.16731-16744. ⟨10.18632/oncotarget.7744⟩. ⟨hal-01376258⟩
  • Isha Pahwa, Noam I. Libeskind, Elmo Tempel, Yehuda Hoffman, R. Brent Tully, et al.. The alignment of galaxy spin with the shear field in observations. Monthly Notices of the Royal Astronomical Society, 2016, 457 (1), pp.695. ⟨10.1093/mnras/stv2930⟩. ⟨in2p3-01247444⟩
  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for pair production of first and second generation leptoquarks in proton-proton collisions at sqrt(s) = 8 TeV. Physical Review D, 2016, 93, pp. 032004 ⟨10.1103/PhysRevD.93.032004⟩. ⟨in2p3-01199144⟩
  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Studies of inclusive four-jet production with two b-tagged jets in proton-proton collisions at 7 TeV. Physical Review D, 2016, 94, pp.112005. ⟨10.1103/PhysRevD.94.112005⟩. ⟨in2p3-01364849⟩
  • V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for a Higgs boson decaying into gamma* gamma to ll gamma with low dilepton mass in pp collisions at sqrt(s) = 8 TeV. Physics Letters B, 2016, 753, pp.341-362. ⟨10.1016/j.physletb.2015.12.039⟩. ⟨in2p3-01279443⟩
  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for neutral resonances decaying into a Z boson and a pair of b jets or tau leptons. Physics Letters B, 2016, 759, pp.369-394. ⟨10.1016/j.physletb.2016.05.087⟩. ⟨in2p3-01285921⟩
  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, B. Fabbro, et al.. Search for new physics with the MT2 variable in all-jets final states produced in pp collisions at sqrt(s) = 13 TeV. Journal of High Energy Physics, 2016, 10(2016), pp.006. ⟨10.1007/JHEP10(2016)006⟩. ⟨in2p3-01288366⟩
  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of transverse momentum relative to dijet systems in PbPb and pp collisions at sqrt(s[NN]) = 2.76 TeV. Journal of High Energy Physics, 2016, 1601, pp.006. ⟨10.1007/JHEP01(2016)006⟩. ⟨in2p3-01207510⟩

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