Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8788 documents

  • R. Stiele, J. Schaffner-Bielich. Phase diagram and nucleation in the Polyakov-loop-extended Quark-Meson truncation of QCD with the unquenched Polyakov-loop potential. Physical Review D, 2016, 93, pp.094014. ⟨10.1103/PhysRevD.93.094014⟩. ⟨in2p3-01333331⟩
  • Alexis Vallard, Sophie Espenel, Jean-Baptiste Guy, Peng Diao, Yaoxiong Xia, et al.. Targeting stem cells by radiation: From the biological angle to clinical aspects . World Journal of Stem Cells, 2016, 8 (8), pp.243-250. ⟨10.4252/WJSC.v8.i8.243⟩. ⟨hal-01375903⟩
  • A. Abdalgabar, A. S. Cornell, A. Deandrea, M. Mcgarrie. Natural supersymmetry and unification in five dimensions. Journal of High Energy Physics, 2016, 2016 (1), pp.83. ⟨10.1007/JHEP01(2016)083⟩. ⟨in2p3-01155683⟩
  • J. Adam, Laurent Aphecetche, A. Baldisseri, Guillaume Batigne, I. Belikov, et al.. Direct photon production in Pb-Pb collisions at \sqrt{s_\rm{NN}} = 2.76 TeV. Physics Letters B, 2016, 754, pp.235-248. ⟨10.1016/j.physletb.2016.01.020⟩. ⟨in2p3-01205166⟩
  • J. Adam, Laurent Aphecetche, A. Baldisseri, Guillaume Batigne, I. Belikov, et al.. Measurement of electrons from heavy-flavour hadron decays in p-Pb collisions at \sqrt{s_{\rm NN}} = 5.02 TeV. Physics Letters B, 2016, 754, pp.81-93. ⟨10.1016/j.physletb.2015.12.067⟩. ⟨in2p3-01205168⟩
  • J. Adam, Laurent Aphecetche, A. Baldisseri, Guillaume Batigne, I. Belikov, et al.. Transverse momentum dependence of D-meson production in Pb-Pb collisions at \sqrt{s_{\rm NN}}=2.76 TeV. Journal of High Energy Physics, 2016, 1603, pp.081. ⟨10.1007/JHEP03(2016)081⟩. ⟨in2p3-01204506⟩
  • D. Zaritsky, K. Mccabe, M. Aravena, E. Athanassoula, A. Bosma, et al.. Globular Cluster Populations: Results Including S^4G Late-Type Galaxies. The Astrophysical Journal, 2016, 818, pp.99. ⟨10.3847/0004-637X/818/1/99⟩. ⟨in2p3-01299853⟩
  • V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for W' decaying to tau lepton and neutrino in proton-proton collisions at sqrt(s) = 8 TeV. Physics Letters B, 2016, 755, pp.196-216. ⟨10.1016/j.physletb.2016.02.002⟩. ⟨in2p3-01186099⟩
  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for the production of an excited bottom quark decaying to tW in proton-proton collisions at sqrt(s) = 8 TeV. Journal of High Energy Physics, 2016, 2016(01), pp.166. ⟨10.1007/JHEP01(2016)166⟩. ⟨in2p3-01206391⟩
  • V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of the charge asymmetry in top quark pair production in pp collisions at sqrt(s) = 8 TeV using a template method. Physical Review D, 2016, 93, pp.034014. ⟨10.1103/PhysRevD.93.034014⟩. ⟨in2p3-01186112⟩

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