Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • J. Adam, Laurent Aphecetche, A. Baldisseri, Guillaume Batigne, I. Belikov, et al.. Direct photon production in Pb-Pb collisions at \sqrt{s_\rm{NN}} = 2.76 TeV. Physics Letters B, 2016, 754, pp.235-248. ⟨10.1016/j.physletb.2016.01.020⟩. ⟨in2p3-01205166⟩
  • J. Adam, Laurent Aphecetche, A. Baldisseri, Guillaume Batigne, I. Belikov, et al.. Measurement of electrons from heavy-flavour hadron decays in p-Pb collisions at \sqrt{s_{\rm NN}} = 5.02 TeV. Physics Letters B, 2016, 754, pp.81-93. ⟨10.1016/j.physletb.2015.12.067⟩. ⟨in2p3-01205168⟩
  • V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Phenomenological MSSM interpretation of CMS searches in pp collisions at sqrt(s) = 7 and 8 TeV. Journal of High Energy Physics, 2016, 10(2016), pp.129. ⟨10.1007/JHEP10(2016)129⟩. ⟨in2p3-01331544⟩
  • Alexis Vallard, Sophie Espenel, Jean-Baptiste Guy, Peng Diao, Yaoxiong Xia, et al.. Targeting stem cells by radiation: From the biological angle to clinical aspects . World Journal of Stem Cells, 2016, 8 (8), pp.243-250. ⟨10.4252/WJSC.v8.i8.243⟩. ⟨hal-01375903⟩
  • V.M. Abazov, U. Bassler, G. Bernardi, M. Besançon, D. Brown, et al.. Measurement of the Top Quark Mass Using the Matrix Element Technique in Dilepton Final States. Physical Review D, 2016, 94, pp.032004. ⟨10.1103/PhysRevD.94.032004⟩. ⟨in2p3-01330122⟩
  • K. Akiba, R Boussarie, E. Chapon, C Cheshkov, J.-y Grossiord, et al.. LHC forward physics. Journal of Physics G: Nuclear and Particle Physics, 2016, 43 (11), ⟨10.1088/0954-3899/43/11/110201⟩. ⟨in2p3-01399924⟩
  • V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Inclusive and differential measurements of the t t-bar charge asymmetry in pp collisions at sqrt(s) = 8 TeV. Physics Letters B, 2016, 757, pp.154-179. ⟨10.1016/j.physletb.2016.03.060⟩. ⟨in2p3-01334137⟩
  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for pair-produced vector-like B quarks in proton-proton collisions at sqrt(s) = 8 TeV. Physical Review D, 2016, 93, pp.112009 ⟨10.1103/PhysRevD.93.112009⟩. ⟨in2p3-01180714⟩
  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of differential cross sections for Higgs boson production in the diphoton decay channel in pp collisions at sqrt(s)=8 TeV. European Physical Journal C: Particles and Fields, 2016, 76, pp.13. ⟨10.1140/epjc/s10052-015-3853-3⟩. ⟨in2p3-01188998⟩
  • V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for anomalous single top quark production in association with a photon in pp collisions at sqrt(s) = 8 TeV. Journal of High Energy Physics, 2016, 04, pp.035. ⟨10.1007/JHEP04(2016)035⟩. ⟨in2p3-01228467⟩

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