Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • S. Hohenegger, A. Iqbal, Soo-Jong Rey. Instanton-Monopole Correspondence from M-Branes on \mathbb{S}^1 and Little String Theory. Physical Review D, 2016, 93, pp.066016. ⟨10.1103/PhysRevD.93.066016⟩. ⟨in2p3-01296490⟩
    • J. Adam, Laurent Aphecetche, B. Audurier, A. Baldisseri, Guillaume Batigne, et al.. ^{3}_{\Lambda}\mathrm H and ^{3}_{\bar{\Lambda}} \overline{\mathrm H} production in Pb-Pb collisions at \sqrt{s_{\rm NN}} = 2.76 TeV. Physics Letters B, 2016, 754, pp.360-372. ⟨10.1016/j.physletb.2016.01.040⟩. ⟨in2p3-01169683⟩
    • T. Adams, C.A. Carrillo Montoya, B. Courbon, P. Depasse, H. El Mamouni, et al.. Beam test evaluation of electromagnetic calorimeter modules made from proton-damaged PbWO4 crystals. Journal of Instrumentation, 2016, 11, pp.P04012. ⟨10.1088/1748-0221/11/04/P04012⟩. ⟨in2p3-01326343⟩
    • Shady Kotb, Alexandre Detappe, François Lux, Florence Appaix, Emmanuel L. Barbier, et al.. Gadolinium-Based Nanoparticles and Radiation Therapy for Multiple Brain Melanoma Metastases: Proof of Concept before Phase I Trial. Theranostics, 2016, 6 (3), pp.418-427. ⟨10.7150/thno.14018⟩. ⟨hal-01266945⟩
    • M. Martini, N. Jachowicz, M. Ericson, V. Pandey, T. van Cuyck, et al.. Electron-neutrino scattering off nuclei from two different theoretical perspectives. Physical Review C, 2016, 94, pp.015501. ⟨10.1103/PhysRevC.94.015501⟩. ⟨in2p3-01274164⟩
    • J. Comparat, C.-H. Chuang, S. Rodríguez-Torres, M. Pellejero-Ibanez, F. Prada, et al.. The Low Redshift survey at Calar Alto (LoRCA). Monthly Notices of the Royal Astronomical Society, 2016, 458 (3), pp.2940-2952. ⟨10.1093/mnras/stw326⟩. ⟨in2p3-01215809⟩
    • J. Adam, J.L. Aphecetche, B. Audurier, I. Belikov, H. Borel, et al.. Centrality dependence of \mathbf{\psi}(2S) suppression in p-Pb collisions at \mathbf{\sqrt{{\textit s}_{\rm NN}}} = 5.02 TeV. Journal of High Energy Physics, 2016, 06, pp.050. ⟨10.1007/JHEP06(2016)050⟩. ⟨in2p3-01286525⟩
    • J. Adam, Laurent Aphecetche, A. Baldisseri, Guillaume Batigne, I. Belikov, et al.. Measurement of an excess in the yield of J/\psi at very low p_{\rm T} in Pb-Pb collisions at \sqrt{s_{\rm NN}} = 2.76 TeV. Physical Review Letters, 2016, 116, pp.222301 ⟨10.1103/PhysRevLett.116.222301⟩. ⟨in2p3-01207016⟩
    • Cyrus Chargari, Karyn A. Goodman, Ibrahima Diallo, Jean-Baptiste Guy, Chloé Rancoule, et al.. Risk of second cancers in the era of modern radiation therapy: does the risk/benefit analysis overcome theoretical models?. Cancer and Metastasis Reviews, 2016, 35 (2), pp.277-288. ⟨10.1007/s10555-016-9616-2⟩. ⟨hal-01404955⟩
    • Y. Hoffman, A. Nusser, H.M. Courtois, R.B. Tully. Goodness-of-fit analysis of the Cosmicflows-2 database of velocities. Monthly Notices of the Royal Astronomical Society, 2016, 461, pp.4176-4181. ⟨10.1093/mnras/stw1603⟩. ⟨in2p3-01317106⟩

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