Health (PRISME)
- Presentation
- Activities
- Members
- Publications
The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.
Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.
One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.
The activities can be divided into three research areas:
Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.
Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.
Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.
NON-PERMANENTS:
- DOCTORANTS / DOCTORAL STUDENTS:
- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
- V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of the charge asymmetry in top quark pair production in pp collisions at sqrt(s) = 8 TeV using a template method. Physical Review D, 2016, 93, pp.034014. ⟨10.1103/PhysRevD.93.034014⟩. ⟨in2p3-01186112⟩
- V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Combined search for anomalous pseudoscalar HVV couplings in VH production and H to VV decay. Physics Letters B, 2016, 759, pp.672-696. ⟨10.1016/j.physletb.2016.06.004⟩. ⟨in2p3-01274541⟩
- V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Y(nS) polarizations versus particle multiplicity in pp collisions at sqrt(s) = 7 TeV. Physics Letters B, 2016, 761, pp.31-52. ⟨10.1016/j.physletb.2016.07.065⟩. ⟨in2p3-01285920⟩
- V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for W' decaying to tau lepton and neutrino in proton-proton collisions at sqrt(s) = 8 TeV. Physics Letters B, 2016, 755, pp.196-216. ⟨10.1016/j.physletb.2016.02.002⟩. ⟨in2p3-01186099⟩
- V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for new phenomena in monophoton final states in proton-proton collisions at sqrt(s) = 8 TeV. Physics Letters B, 2016, 755, pp.102-124. ⟨10.1016/j.physletb.2016.01.057⟩. ⟨in2p3-01294909⟩
- D. Zaritsky, K. Mccabe, M. Aravena, E. Athanassoula, A. Bosma, et al.. Globular Cluster Populations: Results Including S
G Late-Type Galaxies. The Astrophysical Journal, 2016, 818, pp.99. ⟨10.3847/0004-637X/818/1/99⟩. ⟨in2p3-01299853⟩ - R. A. Briceno, T. D. Cohen, S. Coito, J. J. Dudek, E. Eichten, et al.. Issues and Opportunities in Exotic Hadrons. Chinese Physics C, 2016, 40, pp.042001. ⟨10.1088/1674-1137/40/4/042001⟩. ⟨in2p3-01232853⟩
- J. B. R. Battat, I. G. Irastorza, Alexander Aleksandrov, A.M. Guler, T. Asada, et al.. Readout technologies for directional WIMP Dark Matter detection. Physics Reports, 2016, 662, pp.1-46. ⟨10.1016/j.physrep.2016.10.001⟩. ⟨in2p3-01378972⟩
- J. Adam, Laurent Aphecetche, A. Baldisseri, Guillaume Batigne, I. Belikov, et al.. Direct photon production in Pb-Pb collisions at
= 2.76 TeV. Physics Letters B, 2016, 754, pp.235-248. ⟨10.1016/j.physletb.2016.01.020⟩. ⟨in2p3-01205166⟩ - J. Adam, Laurent Aphecetche, A. Baldisseri, Guillaume Batigne, I. Belikov, et al.. Measurement of electrons from heavy-flavour hadron decays in p-Pb collisions at
TeV. Physics Letters B, 2016, 754, pp.81-93. ⟨10.1016/j.physletb.2015.12.067⟩. ⟨in2p3-01205168⟩
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