Health

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:

SAADE Gaëlle

8788 documents

V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of differential and integrated fiducial cross sections for Higgs boson production in the four-lepton decay channel in pp collisions at sqrt(s) = 7 and 8 TeV. Journal of High Energy Physics, 2016, 04 (4), pp.005. ⟨10.1007/JHEP04(2016)005⟩. ⟨in2p3-01249888⟩
A.N. N Turanov, V.K. K Karandashev, M. Boltoeva, C. Gaillard, V. Mazan. Synergistic extraction of uranium(VI) with TODGA and hydrophobic ionic liquid mixtures into molecular diluent. Separation and Purification Technology, 2016, 164, pp.97-106. ⟨10.1016/j.seppur.2016.03.004⟩. ⟨hal-03009872⟩
D.N. Blaschke, F. Gieres, M. Reboud, M. Schweda. The Energy-Momentum Tensor(s) in Classical Gauge Theories. Nuclear Physics B, 2016, 912, pp.192-223. ⟨10.1016/j.nuclphysb.2016.07.001⟩. ⟨in2p3-01315387⟩
V.M. Abazov, U. Bassler, G. Bernardi, M. Besançon, D. Brown, et al.. Measurement of the forward-backward asymmetry of $\Lambda$ and $\bar{\Lambda}$ production in $p \bar{p}$ collisions. Physical Review D, 2016, 93, pp.032002. ⟨10.1103/PhysRevD.93.032002⟩. ⟨in2p3-01229593⟩
Chloé Rancoule, Alexis Vallard, Sophie Espenel, Jean-Baptiste Guy, Yaoxiong Xia, et al.. Immunotherapy in head and neck cancer: Harnessing profit on a system disruption. Oral Oncology, 2016, 62, pp.153-162. ⟨10.1016/j.oraloncology.2016.09.002⟩. ⟨hal-01375889⟩
J. Adam, H. Borel, V.J.G. Feuillard, B. Hippolyte, C. Kuhn, et al.. Multi-strange baryon production in p-Pb collisions at $\sqrt{s_\mathbf{NN}}=5.02$ . Physics Letters B, 2016, 758, pp.389-401. ⟨10.1016/j.physletb.2016.05.027⟩. ⟨in2p3-01249887⟩
J. Adam, Laurent Aphecetche, B. Audurier, A. Baldisseri, Guillaume Batigne, et al.. D-meson production in p-Pb collisions at $\sqrt{s_{\rm NN}}=5.02$ TeV and in pp collisions at $\sqrt{s}=7$ TeV. Physical Review C, 2016, 94, pp.054908. ⟨10.1103/PhysRevC.94.054908⟩. ⟨in2p3-01322322⟩
J. Adam, G. Conesa Balbastre, J. Faivre, C. Furget, R. Guernane, et al.. Centrality dependence of the nuclear modification factor of charged pions, kaons, and protons in Pb-Pb collisions at $\sqrt{s_{\rm NN}}=2.76$ TeV. Physical Review C, 2016, 93, pp.034913. ⟨10.1103/PhysRevC.93.034913⟩. ⟨in2p3-01172195⟩
J. Adam, Laurent Aphecetche, B. Audurier, A. Baldisseri, Guillaume Batigne, et al.. Centrality dependence of pion freeze-out radii in Pb-Pb collisions at $\sqrt{\mathbf{s_{NN}}}$ =2.76 TeV. Physical Review C, 2016, 93, pp.024905 ⟨10.1103/PhysRevC.93.024905⟩. ⟨in2p3-01180410⟩
J. Adam, Laurent Aphecetche, A. Baldisseri, Guillaume Batigne, I. Belikov, et al.. Azimuthal anisotropy of charged jet production in $\sqrt{s_{\rm NN}}$ = 2.76 TeV Pb-Pb collisions. Physics Letters B, 2016, 753, pp.511-525. ⟨10.1016/j.physletb.2015.12.047⟩. ⟨in2p3-01205167⟩

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