Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8788 documents

  • I. Jozwik, J. Jagielski, G. Gawlik, P. Jozwik, R. Ratajczak, et al.. Comparative study of radiation-induced damage in magnesium aluminate spinel by means of IL, CL and RBS/C techniques. Physics and Chemistry of Minerals, 2016, 43 (6), pp.439-445. ⟨10.1007/s00269-016-0807-8⟩. ⟨in2p3-01338228⟩
  • D. Davesne, P. Becker, A. Pastore, J. Navarro. Infinite matter properties and zero-range limit of nonrelativistic finite-range interactions. Annals of Physics, 2016, 375, pp.288 - 312. ⟨10.1016/j.aop.2016.10.013⟩. ⟨in2p3-01424860⟩
  • G. Cacciapaglia, F. Sannino. An Ultraviolet Chiral Theory of the Top for the Fundamental Composite (Goldstone) Higgs. Physics Letters B, 2016, 755, pp.328-331. ⟨10.1016/j.physletb.2016.02.034⟩. ⟨in2p3-01192632⟩
  • M. González-Alonso, J.M. Camalich. Global Effective-Field-Theory analysis of New-Physics effects in (semi)leptonic kaon decays. Journal of High Energy Physics, 2016, 52, ⟨10.1007/JHEP12(2016)052⟩. ⟨in2p3-01327906⟩
  • S. Mannai, K. Manai, E. Cortina, I. Laktineh. Energy Reconstruction in a High Granularity Semi-Digital Hadronic Calorimeter for ILC Experiments. IEEE Transactions on Nuclear Science, 2016, 63 (6), pp.2880-2886. ⟨10.1109/TNS.2016.2614946⟩. ⟨hal-01554664⟩
  • E. Carlesi, J.G. Sorce, Y. Hoffman, S. Gottlöber, G. Yepes, et al.. Constrained Local UniversE Simulations: A Local Group Factory. Monthly Notices of the Royal Astronomical Society, 2016, 458, pp.900-911. ⟨10.1093/mnras/stw357⟩. ⟨in2p3-01274162⟩
  • S. Aghion, C. Amsler, A. Ariga, T. Ariga, G. Bonomi, et al.. Laser excitation of the n=3 level of positronium for antihydrogen production. Physical Review A : Atomic, molecular, and optical physics [1990-2015], 2016, 94 (1), pp.012507. ⟨10.1103/PhysRevA.94.012507⟩. ⟨in2p3-01343897⟩
  • V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of the mass of the top quark in decays with a J/psi meson in pp collisions at 8 TeV. Journal of High Energy Physics, 2016, 12, pp.123. ⟨10.1007/JHEP12(2016)123⟩. ⟨in2p3-01353566⟩
  • V. Khachatryan, S. Ganjour, A. Givernaud, P. Gras, G. Hamel De Monchenault, et al.. Search for lepton flavour violating decays of the Higgs boson to e tau and e mu in proton-proton collisions at sqrt(s)=8 TeV. Physics Letters B, 2016, 763, pp.472. ⟨10.1016/j.physletb.2016.09.062⟩. ⟨in2p3-01346036⟩
  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for direct pair production of supersymmetric top quarks decaying to all-hadronic final states in pp collisions at sqrt(s) = 8 TeV. European Physical Journal C: Particles and Fields, 2016, 76, pp.460. ⟨10.1140/epjc/s10052-016-4292-5⟩. ⟨in2p3-01281909⟩

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