Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

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- DOCTORANTS / DOCTORAL STUDENTS:
    8790 documents

    • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for supersymmetry in events with soft leptons, low jet multiplicity, and missing transverse momentum in proton-proton collisions at sqrt(s) = 8 TeV. Physics Letters B, 2016, 759, pp.9-35. ⟨10.1016/j.physletb.2016.05.033⟩. ⟨in2p3-01249889⟩
    • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for s channel single top quark production in pp collisions at sqrt(s) = 7 and 8 TeV. Journal of High Energy Physics, 2016, 09, pp.027. ⟨10.1007/JHEP09(2016)027⟩. ⟨in2p3-01285309⟩
    • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of the differential cross section and charge asymmetry for inclusive pp to W + X production at sqrt(s) = 8 TeV. European Physical Journal C: Particles and Fields, 2016, 76, pp.469. ⟨10.1140/epjc/s10052-016-4293-4⟩. ⟨in2p3-01284716⟩
    • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for new physics in same-sign dilepton events in proton-proton collisions at sqrt(s) = 13 TeV. European Physical Journal C: Particles and Fields, 2016, 76, pp.439. ⟨10.1140/epjc/s10052-016-4261-z⟩. ⟨in2p3-01314226⟩
    • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for vector-like charge 2/3 T quarks in proton-proton collisions at sqrt(s) = 8 TeV. Physical Review D, 2016, 93, pp.012003. ⟨10.1103/PhysRevD.93.012003⟩. ⟨in2p3-01199148⟩
    • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of the t-tbar production cross section in the e-mu channel in proton-proton collisions at sqrt(s) = 7 and 8 TeV. Journal of High Energy Physics, 2016, pp.029. ⟨10.1007/JHEP08(2016)029⟩. ⟨in2p3-01285308⟩
    • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for the associated production of a Higgs boson with a single top quark in proton-proton collisions at sqrt(s) = 8 TeV. Journal of High Energy Physics, 2016, 1606, pp.177. ⟨10.1007/JHEP06(2016)177⟩. ⟨in2p3-01206392⟩
    • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of electroweak production of a W boson and two forward jets in proton-proton collisions at sqrt(s) = 8 TeV. Journal of High Energy Physics, 2016, 11, pp.147. ⟨10.1007/JHEP11(2016)147⟩. ⟨in2p3-01348859⟩
    • Brent Huisman, Jean Michel Létang, Etienne Testa, David Sarrut. Accelerated prompt gamma estimation for clinical proton therapy simulations. Physics in Medicine and Biology, 2016, 61 (21), pp.7725-7743. ⟨10.1088/0031-9155/61/21/7725⟩. ⟨hal-01391649⟩
    • N. Abgrall, J. Dumarchez, M. Pavin, B. A. Popov, A. Robert, et al.. Measurements of \pi^{\pm} differential yields from the surface of the T2K replica target for incoming 31 GeV/c protons with the NA61/SHINE spectrometer at the CERN SPS. European Physical Journal C: Particles and Fields, 2016, 76, pp.617. ⟨10.1140/epjc/s10052-016-4440-y⟩. ⟨in2p3-01299022⟩

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