Health

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:

SAADE Gaëlle

8786 documents

V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of the ratio B(B[0,s] to J/psi f0(980) )/B(B[0,s] to J/psi phi(1020)) in pp collisions at sqrt(s) = 7 TeV. Physics Letters B, 2016, 756, pp.84-102. ⟨10.1016/j.physletb.2016.02.047⟩. ⟨in2p3-01128673⟩
J. Adam, Laurent Aphecetche, B. Audurier, A. Baldisseri, Guillaume Batigne, et al.. Anisotropic flow of charged particles in Pb-Pb collisions at $\sqrt{s_{\rm NN}}=5.02$ TeV. Physical Review Letters, 2016, 116, pp.132302. ⟨10.1103/PhysRevLett.116.132302⟩. ⟨in2p3-01267136⟩
V.M. Abazov, F. Badaud, Ph. Gris, G. Grenier, T. Kurca, et al.. $B^{0}_{s}$ lifetime measurement in the CP-odd decay channel $B^{0}_{s} \to J/\psi\mbox{ }f_{0}(980)$ . Physical Review D, 2016, 96, pp.012001. ⟨10.1103/PhysRevD.94.012001⟩. ⟨in2p3-01283982⟩
J. Adam, G. Conesa Balbastre, J. Faivre, C. Furget, R. Guernane, et al.. Search for weakly decaying $\overline{\Lambda\mathrm{n}}$ and $\Lambda\Lambda$ exotic bound states in central Pb-Pb collisions at $\sqrt{s_{\rm NN}}$ = 2.76 TeV. Physics Letters B, 2016, 752, pp.267-277. ⟨10.1016/j.physletb.2015.11.048⟩. ⟨in2p3-01172187⟩
Pablo Moreno-Acosta, Schyrly Carrillo, Oscar Gamboa, Alfredo Romero-Rojas, Jinneth Acosta, et al.. Novel predictive biomarkers for cervical cancer prognosis. Molecular and Clinical Oncology, 2016, 5 (6), pp.792-796. ⟨10.3892/mco.2016.1055⟩. ⟨hal-01610086⟩
J.J. Li, W.H. Long, J.L. Song, Q. Zhao. Pseudospin-orbit splitting and its consequences for the central depression in nuclear density. Physical Review C, 2016, 93, pp.054312. ⟨10.1103/PhysRevC.93.054312⟩. ⟨in2p3-01321752⟩
V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for single production of scalar leptoquarks in proton-proton collisions at sqrt(s) = 8 TeV. Physical Review D, 2016, 93, pp.032005. ⟨10.1103/PhysRevD.93.032005⟩. ⟨in2p3-01199145⟩
V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for pair-produced vector-like B quarks in proton-proton collisions at sqrt(s) = 8 TeV. Physical Review D, 2016, 93, pp.112009 ⟨10.1103/PhysRevD.93.112009⟩. ⟨in2p3-01180714⟩
V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for narrow resonances in dijet final states at sqrt(s)=8 TeV with the novel CMS technique of data scouting. Physical Review Letters, 2016, 117, pp.031802. ⟨10.1103/PhysRevLett.117.031802⟩. ⟨in2p3-01310279⟩
V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Correlations between jets and charged particles in PbPb and pp collisions at sqrt(s[NN])= 2.76 TeV. Journal of High Energy Physics, 2016, 02, pp.156. ⟨10.1007/JHEP02(2016)156⟩. ⟨in2p3-01250550⟩

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