Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • P. Yzombard, C. Amsler, T. Ariga, G. Bonomi, P. Bräunig, et al.. Overview of recent work on laser excitation of positronium for the formation of antihydrogen. 12th International Conference on Low Energy Antiproton Physics, Mar 2016, Kanazawa, Japan. pp.011026, ⟨10.7566/JPSCP.18.011026⟩. ⟨hal-01669685⟩
  • A.L. Cunrath Pequegnot. New physics in final states with jets or vector bosons. 30th Rencontres de Physique de La Vallée d'Aoste, Mar 2016, La Thuile, Italy. pp.347, ⟨10.1393/ncc/i2016-16347-1⟩. ⟨hal-01555130⟩
  • M. Gouzevitch, Fabienne Lagarde, I. Laktineh, V. Buridon, X. Chen, et al.. High rate, fast timing Glass RPC for the high \eta CMS muon detectors. XIII Workshop on Resistive Plate Chambers and Related Detectors, Feb 2016, Ghent, Belgium. ⟨in2p3-01327074⟩
  • A. Fagot, A. Cimmino, S. Crucy, M. Gul, A. A. O. Rios, et al.. R&D towards the CMS RPC Phase-2 upgrade. 13th Workshop on Resistive Plate Chambers and Related Detectors (RPC2016), Feb 2016, Ghent, Belgium. pp.C09017, ⟨10.1088/1748-0221/11/09/C09017⟩. ⟨in2p3-01337618⟩
  • Fabienne Lagarde, M. Gouzevitch, I. Laktineh, V. Buridon, X. Chen, et al.. High rate, fast timing Glass RPC for the high {\eta} CMS muon detectors. XIIIth Workshop on Resistive Plate Chambers and related detectors, Feb 2016, Ghent, Belgium. pp.C09006, ⟨10.1088/1748-0221/11/09/C09006⟩. ⟨in2p3-01327680⟩
  • G. Grenier. Performance of the SDHCAL technological prototype. 13th Workshop on Resistive Plate Chambers and Related Detectors (RPC2016), Feb 2016, Ghent, Belgium. pp.C07009, ⟨10.1088/1748-0221/11/07/C07009⟩. ⟨in2p3-01314434⟩
  • M. Shopova, Alexander Aleksandrov, R. Hadjiiska, P. Iaydjiev, G. Sultanov, et al.. Performance of Resistive Plate Chambers installed during the first long shutdown of the CMS experiment. 13th Workshop on Resistive Plate Chambers and Related Detectors (RPC2016), Feb 2016, Ghent, Belgium. ⟨in2p3-01327899⟩
  • K. S. Lee, S. Choi, B. S. Hong, M. Jo, J. W. Kang, et al.. Radiation Tests of Real-Sized Prototype RPCs for the Future CMS RPC Upscope. The XIII workshop on Resistive Plate Chambers and Related Detectors (RPC2016), Feb 2016, Gent, Belgium. pp.C08008, ⟨10.1088/1748-0221/11/08/C08008⟩. ⟨in2p3-01313686⟩
  • F. Wang, D. Han, B. Xie, Y. Wang, P. Lyu, et al.. Performance study of a Mosaic high rate MRPC. 13th Workshop on Resistive Plate Chambers and Related Detectors (RPC2016), Feb 2016, Ghent, Belgium. pp.C09016, ⟨10.1088/1748-0221/11/09/C09016⟩. ⟨in2p3-01372264⟩
  • C. Mancuso. Search for deformation in neutron rich nuclei. IIIrd Topical Workshop on Modern Aspects in Nuclear Structure, Feb 2016, Bormio, Italy. ⟨in2p3-02101724⟩

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