Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • Claire Rodriguez-Lafrasse. Nanoparticules radiosensibilisantes : rĂŞve d’hier, rĂ©alitĂ© de demain. Forum de la recherche en cancĂ©rologie RhĂ´ne-Alpes Auvergne, Mar 2016, Lyon, France. ⟨hal-01297925⟩
    • Jean-Baptiste Guy, BenoĂ®te MĂ©ry, Anne-Sophie Wozny, Priscillia Battiston-Montagne, Dominique Ardail, et al.. Ciblage de la famille HER dans les cancers ORL : inhibition de la prolifĂ©ration cellulaire et de l’invasion-migration cellulaire en rĂ©ponse Ă  l’association cetuximab-pertuzumab combinĂ©e Ă  l’irradiation photonique. Forum de la recherche en cancĂ©rologie RhĂ´ne-Alpes Auvergne, Mar 2016, Lyon, France. ⟨hal-01277945⟩
    • Mattia Fontana, L. Balleyguier, E. Bechetoille, D. Bon, L. Caponetto, et al.. Time-of-Flight Collimated- and Compton-Cameras Development for Ion Beam Therapy Monitoring. Forum de la recherche en cancĂ©rologie RhĂ´ne-Alpes Auvergne, Mar 2016, Lyon, France. ⟨hal-01297637⟩
    • D. Ardail, M. Gilormini, C. Maleysis, C. Rodriguez-Lafrasse. Preferential targeting of cancer stem cells in the radiosensitizing effect of ABT-737 on Head and Neck Squamous Cell Carcinoma. Forum de la recherche en cancĂ©rologie RhĂ´ne-Alpes Auvergne, Mar 2016, Lyon, France. ⟨hal-01277897⟩
    • Anne-Sophie Wozny, Alexandra Lauret, Yannick Saintigny, Priscillia Battiston-Montagne, MichaĂ«l Beuve, et al.. Essential role of HIF-1α in both resistance to photon and carbon ion exposures and invasiveness of Head and Neck Squamous Cell Carcinoma (HNSCC) cancer stem cells. Forum de la recherche en cancĂ©rologie RhĂ´ne-Alpes Auvergne, Mar 2016, Lyon, France. ⟨hal-01277916⟩
    • Floriane Poignant. ModĂ©lisation biophysique des effets radiosensibilisants des nanoparticules. Forum de la recherche en cancĂ©rologie RhĂ´ne-Alpes Auvergne, Mar 2016, Lyon, France. ⟨hal-01297474⟩
    • L. Sarrasin, N. Moncoffre, C. Gaillard, Y. Pipon, R. Ducher, et al.. MĂ©canismes d’incorporation et de migration du Mo dans le dioxyde d’uranium stĹ“chiomĂ©trique et sur-stĹ“chiomĂ©trique. JournĂ©es des thèses IRSN, Mar 2016, Le Croisic, France. ⟨in2p3-02096687⟩
    • D. Pagano, C. Amsler, T. Ariga, G. Bonomi, P. Bräunig, et al.. The Weak Equivalence Principle With Antimatter: The AEgIS Experiment At CERN. 51st Rencontres de Moriond on Cosmology, Mar 2016, La Thuile, Italy. pp.161-164. ⟨hal-03627356⟩
    • G. Victor, Y. Pipon, N. Moncoffre, N. BĂ©rerd, Claude Esnouf, et al.. TEM in situ observations of irradiation damage in boron carbide. 4th Workshop on TEM With In Situ Irradiation (WOTWISI-4), Mar 2016, Orsay, France. ⟨in2p3-02096071⟩
    • Guillaume Victor, Yves Pipon, Nathalie Moncoffre, Nicolas BĂ©rerd, Claude Esnouf, et al.. in-situ TEM observations of irradiation damage in boron carbide. Fourth Workshop On TEM With In Situ Irradiation (WOWISI-4), Mar 2016, Orsay, France. ⟨hal-02188768⟩

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