Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:
    8790 documents

    • R.S. Brusa, C. Amsler, T. Ariga, G. Bonomi, P. Bräunig, et al.. The AEgIS experiment at CERN: measuring antihydrogen free-fall in earth’s gravitational field to test WEP with antimatter. 14th International Workshop on Slow Positron Beam Techniques and Applications, May 2016, Matsue, Japan. pp.012014, ⟨10.1088/1742-6596/791/1/012014⟩. ⟨hal-01554883⟩
    • Anne-Laure Pequegnot. Recherche de rĂ©sonances ttbar dans CMS. Top LHC France 2016, May 2016, Clermont-Ferrand, France. ⟨hal-02019054⟩
    • Viola Sordini. Correction en Ă©nergie des jets, CMS overview. Top LHC France 2016, May 2016, Clermont-Ferrand, France. ⟨hal-02018927⟩
    • B. Farizon. Study of biomolecular ion stability in gas-phase by two complementary approaches: Rice-Ring RIKEN and DIAM-IPNL. Fifth joint workshop of the France Korea (FKPPL) and France Japan (TYL/FJPPL), May 2016, SĂ©oul, South Korea. ⟨in2p3-02092995⟩
    • B. Gnoffo, S. Pirrone, G. Politi, M. La Commara, J. P. Wieleczko, et al.. N/Z effect on reaction mechanisms cross sections in the ^{78}Kr+^{40}Ca and ^{86}Kr+^{48}Ca collisions at 10 A MeV. International Workshop on Multi facets of EoS and Clustering, May 2016, Caen, France. pp.403, ⟨10.1393/ncc/i2016-16403-x⟩. ⟨hal-02058484⟩
    • D. Tsimpis. Generalized complex pure backgrounds. Generalized Geometry & T-dualities, May 2016, New-York, United States. ⟨hal-02063793⟩
    • Sacha Davidson.

          \[\mu \rightarrow e \gamma\]

      ÎĽ → e Îł in the 2HDM: an exercise in EFT. European Physical Journal C: Particles and Fields, 2016, 76 (5), pp.258. ⟨10.1140/epjc/s10052-016-4076-y⟩. ⟨in2p3-01255884⟩
    • D. Autiero. Planning for ProtoDUNE dual-phase. Long Baseline Neutrino Committee meeting, Apr 2016, Batavia, Chicago, United States. ⟨in2p3-02108725⟩
    • J.-M. Richard, Qiang Wang, Q. Zhao. Understanding the shortened lifetime of ^3_{\Lambda}H. 2016. ⟨in2p3-01302771⟩
    • Petru Manescu, Hamid Ladjal, Yazid Touileb, Joseph Azencot, Michael Beuve, et al.. 4D POSITRON EMISSION TOMOGRAPHY IMAGE RECONSTRUCTION BASED ON BIOMECHANICAL RESPIRATORY MOTION. IEEE International Symposium on Biomedical Imaging (IEEE ISBI), Apr 2016, Prague, Czech Republic. pp.99-102. ⟨hal-01267527⟩

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