Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • D. Tsimpis. Generalized complex pure backgrounds. Generalized Geometry & T-dualities, May 2016, New-York, United States. ⟨hal-02063793⟩
  • B. Gnoffo, S. Pirrone, G. Politi, M. La Commara, J. P. Wieleczko, et al.. N/Z effect on reaction mechanisms cross sections in the ^{78}Kr+^{40}Ca and ^{86}Kr+^{48}Ca collisions at 10 A MeV. International Workshop on Multi facets of EoS and Clustering, May 2016, Caen, France. pp.403, ⟨10.1393/ncc/i2016-16403-x⟩. ⟨hal-02058484⟩
  • Sacha Davidson.

        \[\mu \rightarrow e \gamma\]

    μ → e γ in the 2HDM: an exercise in EFT. European Physical Journal C: Particles and Fields, 2016, 76 (5), pp.258. ⟨10.1140/epjc/s10052-016-4076-y⟩. ⟨in2p3-01255884⟩
  • D. Autiero. Planning for ProtoDUNE dual-phase. Long Baseline Neutrino Committee meeting, Apr 2016, Batavia, Chicago, United States. ⟨in2p3-02108725⟩
  • J.-M. Richard, Qiang Wang, Q. Zhao. Understanding the shortened lifetime of ^3_{\Lambda}H. 2016. ⟨in2p3-01302771⟩
  • Petru Manescu, Hamid Ladjal, Yazid Touileb, Joseph Azencot, Michael Beuve, et al.. 4D POSITRON EMISSION TOMOGRAPHY IMAGE RECONSTRUCTION BASED ON BIOMECHANICAL RESPIRATORY MOTION. IEEE International Symposium on Biomedical Imaging (IEEE ISBI), Apr 2016, Prague, Czech Republic. pp.99-102. ⟨hal-01267527⟩
  • Yazid Touileb, Petru Manescu, Hamid Ladjal, Joseph Azencot, Michael Beuve, et al.. MOTION-INDUCED MONTE CARLO DOSE CALCULATION USING DEFORMABLE TETRAHEDRAL MESHES. IEEE International Symposium on Biomedical Imaging (IEEE ISBI), Apr 2016, Prague, Czech Republic. pp.1257-1260. ⟨hal-01267508⟩
  • Benoit Courbon. Search for low mass Higgs-boson like resonances at CMS. 24th International Workshop on Deep-Inelastic Scattering and Related Subjects, Apr 2016, Hamburg, Germany. pp.098, ⟨10.22323/1.265.0098⟩. ⟨hal-02073517⟩
  • J. P. Lansberg, M. Anselmino, R. Arnaldi, S. J. Brodsky, V. Chambert, et al.. Single-Transverse-Spin-Asymmetry studies with a fixed-target experiment using the LHC beams (AFTER@LHC). 24th International Workshop on Deep-Inelastic Scattering and Related Subjects (DIS 2016), Apr 2016, Hambourg, Germany. pp.241. ⟨in2p3-01384316⟩
  • B. Courbon. Search for low mass Higgs-boson like resonances at CMS. XXIV International Workshop on Deep-Inelastic Scattering and Related Subjects, Apr 2016, Hamburg, Germany. ⟨in2p3-01396168⟩

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