Health (PRISME)

  • Presentation
  • Activities
  • Members
  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
476 documents

  • Caterina Monini, Etienne Testa, Michael Beuve. NanOx model: how to predict RBE for hadrontherapy. International Marie Sklodowska-Curie Meeting: from Radiation to Innovation in Medicine 2018, Oct 2018, Paris, France. ⟨hal-02050642⟩
  • G. Vogin, A. Wambersie, R. Pötter, M. Beuve, S.E. Combs, et al.. Concepts and terms for dose/volume parameters in carbon-ion radiotherapy: Conclusions of the ULICE taskforce. Cancer/Radiothérapie, 2018, 22 (8), pp.802-809. ⟨10.1016/j.canrad.2017.11.016⟩. ⟨hal-01909661⟩
  • Anne-Sophie Wozny, Gersende Alphonse, Guillaume Vares, Caterina Monini, Jean-Baptiste Guy, et al.. Spatial ROS distribution to explains the differences in the invasion/migration processes of cancer stem cells in response to photons and carbon ions. 64th Annual Meeting of the Radiation Research Society, Sep 2018, Chicago, United States. ⟨hal-02063655⟩
  • Alexandra Lauret, Pierre Philouze, Céline Malésys, Philippe Céruse, Jonathan Lopez, et al.. Transcriptomic profile of HNSCC cancer : from the original site to the circulating tumoral cells. 2018 Radiation Research Society Annual Meeting, Sep 2018, Chicago, United States. ⟨hal-02051060⟩
  • Alexandra Lauret, Pierre Philouze, Céline Malésys, Jonathan Lopez, Philippe Céruse, et al.. Circulating tumor cells in the future of personalized radio(chimio)therapy for HNSCC patients. 64th Annual Meeting of the Radiation Research Society, Sep 2018, Chicago, United States. ⟨hal-02063575⟩
  • Anne-Sophie Wozny, Gersende Alphonse, Guillaume Vares, Caterina Monini, Jean-Baptiste Guy, et al.. Spatial ROS distribution to explains the differences in the invasion/migration processes of cancer stem cells in response to photons and carbon ions?. 44th Annual Meeting of the European Radiation Research Society, Aug 2018, Pecs, Hungary. ⟨hal-02063670⟩
  • Nils Krah, F. Khellaf, Jean Michel Létang, S. Rit, I. Rinaldi. A theoretical comparison of different proton imaging set-ups. The 4th Loma Linda workshop, Aug 2018, Loma Linda, United States. ⟨hal-02048665⟩
  • Anne-Sophie Wozny. Mécanismes moléculaires spécifiques de la réponse aux ions carbone dans les cellules tumorales (souches et non souches) des cancers des Voies Aéro-Digestives Supérieures. Biochimie, Biologie Moléculaire. Université de Lyon, 2018. Français. ⟨NNT : 2018LYSE1120⟩. ⟨tel-03091979⟩
  • Veronica Tessaro, Mariel E. Galassi, Benoit Gervais, Michael Beuve. A single method to calculate multiple ionization cross sections of Air molecules by ion impact. 10TH INTERNATIONAL SYMPOSIUM ON SWIFT HEAVY IONS IN MATTER & 28TH INTERNATIONAL CONFERENCE ON ATOMIC COLLISIONS IN SOLIDS - SHIM-ICACS 2018, Jul 2018, Caen, France. ⟨hal-01875673⟩
  • Mariel E. Galassi, Veronica Tessaro, Benoit Gervais, Michael Beuve. Multiple ionization cross sections for swift ion impact on ne-like molecules. 10TH INTERNATIONAL SYMPOSIUM ON SWIFT HEAVY IONS IN MATTER & 28TH INTERNATIONAL CONFERENCE ON ATOMIC COLLISIONS IN SOLIDS - SHIM-ICACS 2018, Jul 2018, Caen, France. 2018. ⟨hal-01875650⟩

Powered by HAL logo