Health (PRISME)
- Presentation
- Activities
- Members
- Publications
The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.
Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.
One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.
The activities can be divided into three research areas:
Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.
Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.
Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.
NON-PERMANENTS:
- DOCTORANTS / DOCTORAL STUDENTS:
- B. Kubik, R. Barbier, P. Calabria, A. Castera, E. Chabana, et al.. Low noise flux estimate and data quality control monitoring in EUCLID-NISP cosmological survey . Space Telescopes and Instrumentation 2016: Optical, Infrared, and Millimeter Wave, Jun 2016, Edinburgh United Kingdom. pp.99045J, ⟨10.1117/12.2232551⟩. ⟨in2p3-01466018⟩
- A. Uras. Heavy-Ions at the High-Luminosity LHC. Fourth Annual Large Hadron Collider Physics, Jun 2016, Lund, Sweden. pp.177. ⟨in2p3-01461670⟩
- D. Autiero. Planning for ProtoDUNE dual-phase. Long Baseline Neutrino Committee meeting, Jun 2016, Batavia, Chicago, United States. ⟨in2p3-02107255⟩
- D. Contardo. Detector concepts for future colliders. Strategic Workshop on High Energy Particle Physics in Switzerland, Jun 2016, Lake Aegeri, Switzerland. ⟨hal-02063994⟩
- D. Andriot, G. Cacciapaglia, A. Deandrea, N. Deutschmann, D. Tsimpis. Towards Kaluza-Klein Dark Matter on nilmanifolds. Journal of High Energy Physics, 2016, 2016 (6), pp.169. ⟨10.1007/JHEP06(2016)169⟩. ⟨in2p3-01291739⟩
- M. Toppi, Z. Abou-Haidar, C. Agodi, M. A. G. Alvarez, T. Aumann, et al.. Measurement of fragmentation cross sections of C12 ions on a thin gold target with the FIRST apparatus. Physical Review C, 2016, 93 (6), pp.064601. ⟨10.1103/PhysRevC.93.064601⟩. ⟨in2p3-01334107⟩
- D. Montanari, L. Corradi, S. Szilner, G. Pollarolo, A. Goasduff, et al.. Pair neutron transfer in
Ni + 
Sn probed via γ-particle coincidences. Physical Review C, 2016, 93, pp.054623. ⟨10.1103/PhysRevC.93.054623⟩. ⟨in2p3-01324396⟩ - P.-H. Heenen, B. Bally, M. Bender, W. Ryssens, D. Rudolph. Beyond-mean-field correlations and the description of superheavy elements. Nobel Symposium NS 160 : Chemistry and Physics of Heavy and Superheavy Elements, May 2016, Backskog Castle, Sweden. pp.02001, ⟨10.1051/epjconf/201613102001⟩. ⟨in2p3-01425290⟩
- Emeline Queguiner. Search for Low-Mass WIMPS with EDELWEISS. GDR Terascale, May 2016, Nantes, France. ⟨hal-02060073⟩
- B. Gnoffo, S. Pirrone, G. Politi, M. La Commara, J.P. Wieleczko, et al.. N/Z effect on reaction mechanisms cross sections in the
and 
collisions at 10 AMeV. 11th International conference on Clustering Aspects of Nuclear Structure and Dynamics, May 2016, Napoli, Italy. pp.012062, ⟨10.1088/1742-6596/863/1/012062⟩. ⟨hal-01584705⟩
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