Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • V. Andreev, A. Baghdasaryan, K. Begzsuren, A. Belousov, A. Bolz, et al.. Search for QCD Instanton-Induced Processes at HERA in the High-Q^2 Domain. European Physical Journal C: Particles and Fields, 2016, 76 (7), pp.381. ⟨10.1140/epjc/s10052-016-4194-6⟩. ⟨in2p3-01290445⟩
    • M. Feroci, E. Bozzo, S. Brandt, M. Hernanz, M. van Der Klis, et al.. The LOFT mission concept: a status update. Proceedings of the SPIE,, Jun 2016, Edinburgh, United Kingdom. ⟨10.1117/12.2233161⟩. ⟨hal-01400682⟩
    • Pierre-Elie Crouzet, Ludovic Duvet, Paolo Strada, Ralf Kohley, Remi Barbier, et al.. Comparison of persistence in spot versus flat field illumination and single pixel response on a Euclid HAWAII-2RG at ESTEC. SPIE Astronomical Telescopes + Instrumentation 2016, Jun 2016, Edinburgh, United Kingdom. pp.99151E, ⟨10.1117/12.2230836⟩. ⟨hal-02097418⟩
    • C. Buton, P. Fereyre, M. Fournier, F. Mayer, R. Barbier. Electron multiplying CMOS as Shack-Hartmann wavefront sensor. SPIE Astronomical Telescopes + Instrumentation 2016, Jun 2016, Edinburgh, United Kingdom. pp.99151J, ⟨10.1117/12.2232773⟩. ⟨hal-02116514⟩
    • Linda Feketeova. Velocity distributions of a molecule evaporated from mass-selected water nanodroplet. 7th International Meeting on Atomic and Molecular Physics and Chemistry, IMAMPC 2016, Jun 2016, Le Havre, France. ⟨in2p3-02072376⟩
    • F. Berthias, L. Feketeova, H. Abdoul-Carime, Florent Calvo, B. Farizon, et al.. Velocity distribution of molecules sequentially evaporated from H+(H2O)4. 7th International Meeting on Atomic and Molecular Physics and Chemistry (IMAMPC 2016), Jun 2016, Le Havre, France. ⟨in2p3-02086507⟩
    • S. Pirrone, G. Politi, J.P Wieleczko, B. Gnoffo, E. de Filippo, et al.. Isospin influence on the decay modes of compound nuclei produced in the ^{78,86}Kr+^{40,48}Ca at 10 MeV/nucleon. 2nd Sicilia-East Asia workshop on low-energy nuclear physics, Jun 2016, Wako, Japan. pp.366, ⟨10.1393/ncc/i2016-16366-x⟩. ⟨hal-01554886⟩
    • R. Kohley, R. Barbier, B. Kubik, S. Ferriol, J.-C. Clemens, et al.. Random telegraph signal (RTS) and other anomalies in the near-infrared detector systems for the Euclid mission. Space Telescopes and Instrumentation 2016: Optical, Infrared, and Millimeter Wave, Jun 2016, Edinburgh, United Kingdom. ⟨10.1117/12.2233352⟩. ⟨in2p3-01467280⟩
    • T. Maciaszek, A. Ealet, K. Jahnke, E. Prieto, R. Barbier, et al.. Euclid Near Infrared Spectrometer and Photometer instrument concept and first test results obtained for different breadboards models at the end of phase C. SPIE Conference Space Telescopes and Instrumentation 2016: Optical, Infrared, and Millimeter Wave, Jun 2016, Edinburgh, United Kingdom. pp.99040T, ⟨10.1117/12.2232941⟩. ⟨in2p3-01396843⟩
    • A. Waczynski, R. Barbier, S. Cagiano, J. Chen, S. Cheung, et al.. Performance Overview of the Euclid Infrared Focal Plane Detector Subsystems. High Energy, Optical, and Infrared Detectors for Astronomy VII, Jun 2016, Edinburgh, United Kingdom. pp.991511, ⟨10.1117/12.2231641⟩. ⟨hal-02144336⟩

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