Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • E. Bouvier. Top mass measurements at CMS. 38th International Conference on High Energy Physics - 38th ICHEP 2016, Aug 2016, Chicago, United States. ⟨in2p3-01352711⟩
  • S. Hohenegger, A. Iqbal, Soo-Jong Rey. Self-duality and self-similarity of little string orbifolds. Physical Review D, 2016, 94 (4), pp.046006 ⟨10.1103/PhysRevD.94.046006⟩. ⟨in2p3-01314254⟩
  • R. Brent Tully, Hélène M. Courtois, Jenny G. Sorce. COSMICFLOWS-3. The Astronomical Journal, 2016, 152 (2), pp.50. ⟨10.3847/0004-6256/152/2/50⟩. ⟨in2p3-01317107⟩
  • K. Abe, D. Autiero, P. Bartet-Friburg, M. Buizza Avanzini, O. Drapier, et al.. Sensitivity of the T2K accelerator-based neutrino experiment with an Extended run to 20\times10^{21} POT. 2016. ⟨in2p3-01349584⟩
  • A. Phipps, B. Sadoulet, A. Juillard, Y. Jin. An HEMT-Based Cryogenic Charge Amplifier for Sub-kelvin Semiconductor Radiation Detectors. 16th International Workshop on Low Temperature Detectors (LTD 16), Jul 2016, Grenoble, France. pp.505-511, ⟨10.1007/s10909-016-1475-2⟩. ⟨in2p3-01331546⟩
  • Dariia Ternova, Maria Yu Boltoeva, Laure Cointeaux, Clotilde Gaillard, Vitaly Kalchenko, et al.. Dramatic Changes in the Solubilities of Ions Induced by Ligand Addition in Biphasic System D 2 O/DNO 3 //[C 1 C 4 im][Tf 2 N]: A Phenomenological Study. Journal of Physical Chemistry B, 2016, 120 (30), pp.7502-7510. ⟨10.1021/acs.jpcb.6b05424⟩. ⟨hal-03009853⟩
  • Q. Arnaud, J. Billard, A. Juillard. Optimizing Cryogenic Detectors for Low-Mass WIMP Searches. 16th International Workshop on Low Temperature Detectors (LTD 16), Jul 2016, Grenoble, France. pp.308-315, ⟨10.1007/s10909-015-1463-y⟩. ⟨in2p3-01331548⟩
  • J. Billard, M. de Jesus, A. Juillard, E. Queguiner. Characterization and Optimization of EDELWEISS-III FID800 Heat Signals. 16th International Workshop on Low Temperature Detectors (LTD 16), Jul 2016, Grenoble, France. pp.299-307, ⟨10.1007/s10909-016-1500-5⟩. ⟨in2p3-01331547⟩
  • A. Juillard. Status and Prospects of the EDELWEISS-III Direct WIMP Search Experiment. 16th International Workshop on Low Temperature Detectors (LTD 16), Jul 2016, Grenoble, France. pp.897-903, ⟨10.1007/s10909-016-1493-0⟩. ⟨in2p3-01342964⟩
  • V. Sanglard. Recent results on Low Mass WIMP search with the EDELWEISS-III experiment. IDM2016, Jul 2016, Sheffield, United Kingdom. ⟨hal-02060088⟩

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