Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • I.M. Harca, E. Kozulin, E. Vardaci, M. Ashaduzzaman, C. Borcea, et al.. The reaction ^{32}S + ^{197}Au near the interaction barrier. 8th International Symposium on Exotic Nuclei, Sep 2016, Kazan, Russia. pp.236-242, ⟨10.1142/9789813226548_0035⟩. ⟨hal-01646048⟩
    • Anne-Sophie Wozny, Alexandra Lauret, Yannick Saintigny, Priscillia Battiston-Montagne, Michael Beuve, et al.. A key role of HIF-1α in the radioresistance of Cancer Stem Cells in their hypoxic microenvironment. 42nd Conference on the European radiation research society (ERR 2016), Sep 2016, Amsterdam, Netherlands. ⟨hal-01400307⟩
    • A.N. Turanov, C. Gaillard, ValĂ©rie Mazan, S. Georg, V.K. Karandashev, et al.. Extraction de l’uranium(VI) avec un mĂ©lange de TODGA et d’un liquide ionique dans un solvant molĂ©culaire. JournĂ©es de Radiochimie, Sep 2016, Nice, France. ⟨in2p3-02096677⟩
    • G. Aad, Z. Barnovska, N. Berger, M. Delmastro, L. Di Ciaccio, et al.. Measurements of the Higgs boson production and decay rates and constraints on its couplings from a combined ATLAS and CMS analysis of the LHC pp collision data at \sqrt{s}= 7 and 8 TeV. Journal of High Energy Physics, 2016, 08, pp.045. ⟨10.1007/JHEP08(2016)045⟩. ⟨in2p3-01328829⟩
    • J. Kopyra, H. Abdoul-Carime, P. Skurski. Temperature Dependence of the Dissociative Electron Attachment to 2-Thiothymine. Journal of Physical Chemistry A, 2016, 120 (36), pp.7130-7136. ⟨10.1021/acs.jpca.6b06512⟩. ⟨in2p3-01372258⟩
    • C. BaruĂ©, O. Bajeat, J.L. Flambard, R. Frigot, P. Jardin, et al.. Status Report on Metallic Beam Production at GANIL/SPIRAL 2. 22nd International Workshop on ECR Ion Sources (ECRIS2016), Aug 2016, Busan, South Korea. , Joint Accelerator Conferences Website (JACoW), ECRIS 2016, pp.92-97, 2016, ⟨10.18429/JACoW-ECRIS2016-WEPP05⟩. ⟨in2p3-01358180⟩
    • D. Davesne, P. Becker, A. Pastore, J. Navarro. Does the Gogny interaction need a third Gaussian?. Zakopane Conference on Nuclear Physics, Aug 2016, KrakĂłw, Poland. pp.265, ⟨10.5506/APhysPolB.48.265⟩. ⟨hal-02058911⟩
    • T. Thuillier, J. Angot, L. Bonny, J. Jacob, A. Leduc, et al.. First Plasma of the PHOENIX V3 ECR Ion Source. 22nd International Workshop on ECR Ion Sources (ECRIS2016), Aug 2016, Busan, South Korea. pp.48-49 ⟨10.18429/JACoW-ECRIS2016-TUAO05⟩. ⟨in2p3-01357163⟩
    • A. Crivellin, Sacha Davidson, G.M. Pruna, A. Signer. Complementarity in lepton-flavour violating muon decay experiments. 18th International Workshop on Neutrino Factories and Future Neutrino Facilities Search (NuFact16), Aug 2016, Quy Nhon, Vietnam. ⟨in2p3-01398463⟩
    • Marina Chadeeva, Remi Ete, Oskar Hartbrich, Coralie Neubuser, Arnaud Steen, et al.. Test beam performance and detailed studies of the structure of hadronic showers with highly granular calorimeters. 38th International Conference on High Energy Physics, Aug 2016, Chicago, United States. pp.1092, ⟨10.22323/1.282.1092⟩. ⟨hal-01645656⟩

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