Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • G. Victor, Y. Pipon, N. Moncoffre, N. BĂ©rerd, N Toulhoat, et al.. Comparaison de techniques d'analyse par faisceau d'ions ERDA, NRA et SIMS pour profiler le deutĂ©rium dans le carbure de bore B_4C. Ion Beam Analysis Francophone, Sep 2016, Annecy, France. ⟨in2p3-02096585⟩
  • X. Artru. Correlations in thermal vibrations of crystal atoms. Effect on dechanneling and bremsstrahlung. 7th International Conference on Charged & Neutral Particles Channeling Phenomena, Sep 2016, Sirmione, Italy. pp.21-23, ⟨10.1016/j.nimb.2017.03.115⟩. ⟨hal-02058518⟩
  • X. Artru. Spontaneous and stimulated radiations of a classical moving charge from energy conservation. 7th International Conference on Charged & Neutral Particles Channeling Phenomena, Sep 2016, Sirmione, Italy. pp.112-113, ⟨10.1016/j.nimb.2017.03.007⟩. ⟨hal-02058474⟩
  • C. Ray, D. Dauvergne. Proton and light ion deflection at medium energies with planar bent crystals. 7th International Conference “Charged & Neutral Particles Channeling Phenomena” (CHANNELING 2016), Sep 2016, Sirmione, Italy. pp.313-320. ⟨in2p3-01481925⟩
  • A. Kerbizi, X. Artru, Z. Belghobsi, F. Bradamante, A. Martin, et al.. Recursive Monte Carlo code for transversely polarized quark jet. 22nd International Symposium on Spin Physics (SPIN 2016), Sep 2016, Urbana, IL, United States. ⟨in2p3-01468542⟩
  • J-B Guy, B. MĂ©ry, C. Rancoule, A. Vallard, S. Espenel, et al.. HER Family Blockade in Head and Neck Squamous Cell Carcinoma: Couple Therapy Efficacy of Cetuximab and Pertuzumab Combined With Photon Irradiation. 58th Annual Meeting of the American Society for Radiation Oncology, Sep 2016, Boston, United States. pp.E577-E578, ⟨10.1016/j.ijrobp.2016.06.2074⟩. ⟨hal-01400227⟩
  • I. Chaikovska, R. Chehab, X. Artru, A.V. Shchagin. Characteristic, parametric, and diffracted transition X-ray radiation for observation of accelerated particle beam profile. 7th International Conference on Charged & Neutral Particles Channeling Phenomena, Sep 2016, Sirmione, Italy. pp.75-78, ⟨10.1016/j.nimb.2017.03.157⟩. ⟨hal-02058555⟩
  • I. Chaikovska, R. Chehab, H. Guler, P. Sievers, X. Artru, et al.. Optimization of an hybrid positron source using channeling. 7th International Conference on Charged & Neutral Particles Channeling Phenomena, Sep 2016, Sirmione, Italy. pp.58-62, ⟨10.1016/j.nimb.2017.03.012⟩. ⟨hal-02058498⟩
  • E. Testa. Detection of prompt radiations for hadrontherapy verification. Hadrontherapy school - CNAO, France Hadron, LabEx PRIMES, Sep 2016, Pavia, Italy. ⟨hal-01916636⟩
  • Francis Berthias. Thermalisation dans une nanogoutte d’eau. MĂ©canique des fluides [physics.class-ph]. UniversitĂ© de Lyon, 2016. Français. ⟨NNT : 2016LYSE1164⟩. ⟨tel-01430562⟩

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