Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • D. Autiero. ProtoDUNE−DP/1x1x3 m3 update. Long Baseline Neutrino Committee meeting, Oct 2016, Batavia, Chicago, United States. ⟨in2p3-02107250⟩
  • G. Victor, Y. Pipon, N. Moncoffre, N. Bérerd, Claude Esnouf, et al.. TEM in situ observations of irradiation damage in boron carbide. Emirum meeting, Oct 2016, Orsay, France. ⟨in2p3-02096077⟩
  • Benoit Courbon. Reconstruction des photons et recherche d’un second boson de Higgs dans le canal di-photon au sein de l’expérience CMS au LHC. Physique des accélérateurs [physics.acc-ph]. Université de Lyon, 2016. Français. ⟨NNT : 2016LYSE1187⟩. ⟨tel-01487297⟩
  • N. Galy, N Toulhoat, N Moncoffre, Y Pipon, N. Bérerd, et al.. Ion irradiation to simulate neutron irradiation in model graphites: Consequences for nuclear graphite. CAST General Assembly Meeting, Oct 2016, Bucarest, Romania. ⟨in2p3-02094836⟩
  • F. Prelz, S. Aghion, C. Amsler, T. Ariga, G. Bonomi, et al.. The DAQ system for the AE\bar gIS experiment. 22nd International Conference on Computing in High Energy and Nuclear Physics, Oct 2016, San Francisco, United States. pp.032014, ⟨10.1088/1742-6596/898/3/032014⟩. ⟨hal-01669589⟩
  • Alexandre Biguet. Modèles Nambu--Jona-Lasinio pour l’étude des phases de la chromodynamique quantique : qualités des prédictions et phases hautes densités. Physique Nucléaire Théorique [nucl-th]. Université de Lyon, 2016. Français. ⟨NNT : 2016LYSE1179⟩. ⟨tel-01453184⟩
  • J-B Guy, B. Méry, C. Rancoule, A. Vallard, S. Espenel, et al.. Ciblage de la famille HER dans les cancers ORL : efficacité biologique de l’association de cétuximab et de pertuzumab combinée à l’irradiation photonique. 27e Congrès national de la Société française de radiothérapie oncologique, Oct 2016, Paris, France. pp.742, ⟨10.1016/j.canrad.2016.08.078⟩. ⟨hal-01400259⟩
  • A. Wozny, C. Rancoule, B. Méry, J-B Guy, A. Gaumier, et al.. Nrf2 et Keap1 : biomarqueurs prédictifs de radiorésistance des cancers de la tête et du cou ?. 27e Congrès national de la Société française de radiothérapie oncologique, Oct 2016, Paris, France. pp.741-742, ⟨10.1016/j.canrad.2016.08.077⟩. ⟨hal-01400288⟩
  • T. Dupasquier. New reaction chamber for the NEDA+DIAMANT campaign. 17th AGATA Week, Oct 2016, Orsay, France. ⟨in2p3-02101709⟩
  • M Cunha, M Monini, E Testa, M Beuve. NANOX, A MULTI-SCALE MODEL TO PREDICT BIOLOGICAL EFFECTS AND HADRONTHERAPY. International Conference "Dynamics of Systems on the Nanoscale" (DySoN 2016), Oct 2016, Bad Ems, Germany. ⟨hal-01400164⟩

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