Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8788 documents

  • A. Blanchard, S. Camera, C. Carbone, V. F. Cardone, S. Casas, et al.. Euclid preparation. VII. Forecast validation for Euclid cosmological probes. Astronomy & Astrophysics - A&A, 2020, 642, pp.A191. ⟨10.1051/0004-6361/202038071⟩. ⟨hal-02976446⟩
  • Riad Ladjohounlou, Safa Louati, Alexandra Lauret, Arnaud Gauthier, Dominique Ardail, et al.. Ceramide-Enriched Membrane Domains Contribute to Targeted and Nontargeted Effects of Radiation through Modulation of PI3K/AKT Signaling in HNSCC Cells. International Journal of Molecular Sciences, 2020, 21 (19), pp.7200. ⟨10.3390/ijms21197200⟩. ⟨hal-03001763⟩
  • Janina Kopyra, Franck Rabilloud, Hassan Abdoul-Carime. Decomposition of Bis(acetylacetonate)zinc(II) by Slow Electrons. Inorganic Chemistry, 2020, 59 (17), pp.12788-12792. ⟨10.1021/acs.inorgchem.0c01842⟩. ⟨hal-02941349⟩
  • Oreste Allegrini, J.-P Cachemiche, C.P.C. Caplan, B Carlus, X Chen, et al.. Characterization of a beam-tagging hodoscope for hadrontherapy monitoring. Journée d'étude GDR MI2B - LabEx PRIMES sur les moniteurs faisceaux et contrôle en ligne des irradiations biomédicales, Sep 2020, Lyon, France. ⟨hal-03159268⟩
  • Hamid Ladjal, Michael Beuve, Shariat Behzad. Lung Tumor Tracking Based on Patient-Specific Biomechanical Model of the Respiratory System. Computational Biomechanics for Medicine. MICCAI 2019, MICCAI 2018. Springer, Cham. Computational Biomechanics for Medicine, Springer, Cham, pp 5-16, 2020, 978-3-030-42427-5. ⟨hal-02465989⟩
  • Floriane Poignant, Hela Charfi, Chen-Hui Chan, Elise Dumont, David Loffreda, et al.. Monte Carlo simulation of free radical production under keV photon irradiation of gold nanoparticle aqueous solution. Part I: Global primary chemical boost. Radiation Physics and Chemistry, 2020, 172, pp.108790. ⟨10.1016/j.radphyschem.2020.108790⟩. ⟨hal-02498384⟩
  • Xian Huang, Taguhi Yeghoyan, Stéphane Gavarini, Véronique Soulière, Nathalie Millard-Pinard, et al.. Mono-Versus Poly-Crystalline SiC for Nuclear Applications. 2020, pp.139-144. ⟨10.4028/www.scientific.net/MSF.1004.139⟩. ⟨hal-02990900⟩
  • Jane-Chloe Trone, Alexis Vallard, Sandrine Sotton, Majed Ben Mrad, Omar Jmour, et al.. Survival after hypofractionation in glioblastoma: a systematic review and meta-analysis. Radiation Oncology, 2020, 15 (1), pp.145. ⟨10.1186/s13014-020-01584-6⟩. ⟨hal-04805734⟩
  • S. Pires, V. Vandenbussche, V. Kansal, R. Bender, L. Blot, et al.. Euclid: Reconstruction of weak-lensing mass maps for non-Gaussianity studies. Astronomy & Astrophysics - A&A, 2020, 638, pp.A141. ⟨10.1051/0004-6361/201936865⟩. ⟨cea-02882577⟩
  • P. Paykari, T. Kitching, H. Hoekstra, R. Azzollini, V. F. Cardone, et al.. Euclid preparation - VI. Verifying the Performance of Cosmic Shear Experiments (Corrigendum). Astronomy & Astrophysics - A&A, 2020, 638, pp.C2. ⟨10.1051/0004-6361/201936980e⟩. ⟨cea-02813362⟩

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