Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • J. Adam, B. Audurier, A. Baldisseri, Guillaume Batigne, J. Castillo Castellanos, et al.. Anomalous broadening of the near-side jet peak in Pb-Pb collisions at \sqrt{s_{\rm{NN}}} = 2.76 TeV. Physical Review Letters, 2017, 119, pp.102301 ⟨10.1103/PhysRevLett.119.102301⟩. ⟨in2p3-01370108⟩
    • K. Bennaceur, A. Idini, J. Dobaczewski, P. Dobaczewski, M. Kortelainen, et al.. Nonlocal energy density functionals for pairing and beyond-mean-field calculations. Journal of Physics G: Nuclear and Particle Physics, 2017, 44, pp.045106. ⟨10.1088/1361-6471/aa5fd7⟩. ⟨in2p3-01406293⟩
    • E. Armengaud, C. Augier, A.S. Barabash, J.W. Beeman, T.B. Bekker, et al.. Development of 100Mo-containing scintillating bolometers for a high-sensitivity neutrinoless double-beta decay search. European Physical Journal C: Particles and Fields, 2017, 77 (11), pp.785. ⟨10.1140/epjc/s10052-017-5343-2⟩. ⟨hal-01669511⟩
    • Shreyasi Acharya, Jaroslav Adam, Dagmar Adamova, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. Kaon femtoscopy in Pb-Pb collisions at \sqrt{s_{\rm{NN}}} = 2.76 TeV. Phys.Rev.C, 2017, 96 (6), pp.064613. ⟨10.1103/PhysRevC.96.064613⟩. ⟨hal-01703863⟩
    • A. Falkowski, M. Gonzalez-Alonso, A. Greljo, D. Marzocca, M. Son. Anomalous Triple Gauge Couplings in the Effective Field Theory Approach at the LHC. Journal of High Energy Physics, 2017, 02, pp.115. ⟨10.1007/JHEP02(2017)115⟩. ⟨in2p3-01375658⟩
    • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of the WZ production cross section in pp collisions at sqrt(s) = 13 TeV. Physics Letters B, 2017, 766, pp.268. ⟨10.1016/j.physletb.2017.01.011⟩. ⟨in2p3-01348858⟩
    • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for heavy neutrinos or third-generation leptoquarks in final states with two hadronically decaying tau leptons and two jets in proton-proton collisions at sqrt(s) = 13 TeV. Journal of High Energy Physics, 2017, 03 (3), pp.077. ⟨10.1007/JHEP03(2017)077⟩. ⟨in2p3-01409594⟩
    • V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for anomalous Wtb couplings and flavour-changing neutral currents in t-channel single top quark production in pp collisions at sqrt(s) = 7 and 8 TeV. Journal of High Energy Physics, 2017, 02 (2), pp.028. ⟨10.1007/JHEP02(2017)028⟩. ⟨in2p3-01380410⟩
    • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for single production of a heavy vector-like T quark decaying to a Higgs boson and a top quark with a lepton and jets in the final state. Physics Letters B, 2017, 771, pp.80-105. ⟨10.1016/j.physletb.2017.05.019⟩. ⟨in2p3-01409593⟩
    • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Suppression of Upsilon(1S), Upsilon(2S) and Upsilon(3S) production in PbPb collisions at sqrt(s[NN]) = 2.76 TeV. Physics Letters B, 2017, 770, pp.357. ⟨10.1016/j.physletb.2017.04.031⟩. ⟨in2p3-01393197⟩

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