Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for CP violation in top quark-antiquark production and decay in proton-proton collisions at sqrt(s) = 8 TeV. Journal of High Energy Physics, 2017, 03 (3), pp.101. ⟨10.1007/JHEP03(2017)101⟩. ⟨in2p3-01404605⟩
  • J. Adam, I. Belikov, J.C. Hamon, B. Hippolyte, C. Kuhn, et al.. Flow dominance and factorization of transverse momentum correlations in Pb-Pb collisions at the LHC. Physical Review Letters, 2017, 118, pp.162302. ⟨10.1103/PhysRevLett.118.162302⟩. ⟨in2p3-01464131⟩
  • A.M. Sirunyan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for electroweak production of a vector-like quark decaying to a top quark and a Higgs boson using boosted topologies in fully hadronic final states. Journal of High Energy Physics, 2017, 04 (4), pp.136. ⟨10.1007/JHEP04(2017)136⟩. ⟨in2p3-01419177⟩
  • V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Jet energy scale and resolution in the CMS experiment in pp collisions at 8 TeV. Journal of Instrumentation, 2017, 12 (02), pp.P02014. ⟨10.1088/1748-0221/12/02/P02014⟩. ⟨in2p3-01346043⟩
  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for supersymmetry with multiple charged leptons in proton-proton collisions at sqrt(s) = 13 TeV. European Physical Journal C: Particles and Fields, 2017, 77, pp.635. ⟨10.1140/epjc/s10052-017-5182-1⟩. ⟨in2p3-01449457⟩
  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Observation of charge-dependent azimuthal correlations in pPb collisions and its implication for the search for the chiral magnetic effect. Physical Review Letters, 2017, 118 (12), pp.122301. ⟨10.1103/PhysRevLett.118.122301⟩. ⟨in2p3-01376017⟩
  • Shreyasi Acharya, Dagmar Adamova, Jonatan Adolfsson, Madan Mohan Aggarwal, Gianluca Aglieri Rinella, et al.. Linear and non-linear flow modes in Pb-Pb collisions at \sqrt{s_{\rm NN}} = 2.76 TeV. Physics Letters B, 2017, 773, pp.68-80. ⟨10.1016/j.physletb.2017.07.060⟩. ⟨hal-01582582⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Ece Asilar, Thomas Bergauer, et al.. Measurement of the {B}^{\pm} Meson Nuclear Modification Factor in Pb-Pb Collisions at \sqrt{{s}_{NN}}=5.02\text{ }\text{ }\mathrm{TeV}. Physical Review Letters, 2017, 119 (15), pp.152301. ⟨10.1103/PhysRevLett.119.152301⟩. ⟨hal-01669602⟩
  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of the production cross section of the W boson in association with two b jets in pp collisions at sqrt(s) = 8 TeV. European Physical Journal C: Particles and Fields, 2017, 77, pp.92. ⟨10.1140/epjc/s10052-016-4573-z⟩. ⟨in2p3-01357547⟩
  • V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Multiplicity and rapidity dependence of strange hadron production in pp, pPb, and PbPb collisions at the LHC. Physics Letters B, 2017, 768, pp.103-129. ⟨10.1016/j.physletb.2017.01.075⟩. ⟨in2p3-01320601⟩

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