Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Measurement of vector boson scattering and constraints on anomalous quartic couplings from events with four leptons and two jets in proton–proton collisions at \sqrt{s}= 13 TeV. Phys.Lett.B, 2017, 774, pp.682-705. ⟨10.1016/j.physletb.2017.10.020⟩. ⟨hal-01669814⟩
  • Vardan Khachatryan, Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Ece Aşılar, et al.. Measurement of the cross section for electroweak production of Z\gamma in association with two jets and constraints on anomalous quartic gauge couplings in proton–proton collisions at \sqrt{s} = 8 TeV. Phys.Lett.B, 2017, 770, pp.380-402. ⟨10.1016/j.physletb.2017.04.071⟩. ⟨hal-01669817⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Searches for W′ bosons decaying to a top quark and a bottom quark in proton-proton collisions at 13 TeV. JHEP, 2017, 08, pp.029. ⟨10.1007/JHEP08(2017)029⟩. ⟨hal-01669796⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Ece Aşılar, Thomas Bergauer, et al.. Search for third-generation scalar leptoquarks and heavy right-handed neutrinos in final states with two tau leptons and two jets in proton-proton collisions at \sqrt{s}=13 TeV. JHEP, 2017, 07, pp.121. ⟨10.1007/JHEP07(2017)121⟩. ⟨hal-01669784⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Constraints on anomalous Higgs boson couplings using production and decay information in the four-lepton final state. Phys.Lett.B, 2017, 775, pp.1-24. ⟨10.1016/j.physletb.2017.10.021⟩. ⟨hal-01669750⟩
  • Marina Rosas-Carbajal, Kevin Jourde, Jacques Marteau, Sebastien Deroussi, Jean-Christophe Komorowski, et al.. Three-dimensional density structure of La Soufrière de Guadeloupe lava dome from simultaneous muon radiographies and gravity data. Geophysical Research Letters, 2017, 44 (13), pp.6743-6751. ⟨10.1002/2017GL074285⟩. ⟨insu-01561114⟩
  • G. Aarts, Joerg Aichelin, C. Allton, R. Arnaldi, S. A. Bass, et al.. Heavy-flavor production and medium properties in high-energy nuclear collisions - What next?. The European physical journal. A, Hadrons and Nuclei, 2017, 53 (5), pp.93. ⟨10.1140/epja/i2017-12282-9⟩. ⟨in2p3-01424872⟩
  • D. Ralet, S. Pietri, T. Rodríguez, M. Alaqeel, T. Alexander, et al.. Lifetime measurement of neutron-rich even-even molybdenum isotopes. Physical Review C, 2017, 95 (3), pp.034320. ⟨10.1103/PhysRevC.95.034320⟩. ⟨hal-01554441⟩
  • M. Belabbas, J.J. Li, J. Margueron. Finite-temperature pairing re-entrance in the drip-line nucleus ^{48}\text{Ni}. Phys.Rev.C, 2017, 96 (2), pp.024304. ⟨10.1103/PhysRevC.96.024304⟩. ⟨hal-01582397⟩
  • V. Andreev, A. Baghdasaryan, K. Begzsuren, A. Belousov, V. Bertone, et al.. Determination of the strong coupling constant \alpha_s(m_Z) in next-to-next-to-leading order QCD using H1 jet cross section measurements. Eur.Phys.J.C, 2017, 77 (11), pp.791. ⟨10.1140/epjc/s10052-017-5314-7⟩. ⟨hal-01669553⟩

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