Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • Micaela Cunha, Caterina Monini, Etienne Testa, Michael Beuve. NanOx, a new model to predict cell survival in the context of particle therapy. Physics in Medicine and Biology, 2017, 62 (4), pp.1248-1268. ⟨10.1088/1361-6560/aa54c9⟩. ⟨hal-01446509⟩
    • S. Acharya, A. Baldisseri, H. Borel, J. Castillo Castellanos, J.L. Charvet, et al.. Measurement of D-meson production at mid-rapidity in pp collisions at \mathbf{\sqrt{s}=7} TeV. European Physical Journal C: Particles and Fields, 2017, 77, pp.550. ⟨10.1140/epjc/s10052-017-5090-4⟩. ⟨in2p3-01454731⟩
    • Bogna Kubik, Noam I. Libeskind, Alexander Knebe, Hélène Courtois, Gustavo Yepes, et al.. Universal subhalo accretion in cold and warm dark matter cosmologies. Monthly Notices of the Royal Astronomical Society, 2017, 472 (4), pp.4099-4109. ⟨10.1093/mnras/stx2263⟩. ⟨hal-01645726⟩
    • A. Vogt, M. Siciliano, B. Birkenbach, P. Reiter, K. Hadyńska-Klęk, et al.. High-spin structures in ^{132}Xe and ^{133}Xe and evidence for isomers along the N=79 isotones. Physical Review C, 2017, 96 (2), pp.024321. ⟨10.1103/PhysRevC.96.024321⟩. ⟨hal-01582929⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Ece Aşılar, Thomas Bergauer, et al.. Search for new physics with dijet angular distributions in proton-proton collisions at \sqrt{s}=13 TeV. JHEP, 2017, 07, pp.013. ⟨10.1007/JHEP07(2017)013⟩. ⟨hal-01669472⟩
    • A.M. Sirunyan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for electroweak production of a vector-like quark decaying to a top quark and a Higgs boson using boosted topologies in fully hadronic final states. Journal of High Energy Physics, 2017, 04 (4), pp.136. ⟨10.1007/JHEP04(2017)136⟩. ⟨in2p3-01419177⟩
    • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Observation of charge-dependent azimuthal correlations in pPb collisions and its implication for the search for the chiral magnetic effect. Physical Review Letters, 2017, 118 (12), pp.122301. ⟨10.1103/PhysRevLett.118.122301⟩. ⟨in2p3-01376017⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Ece Aşılar, Thomas Bergauer, et al.. Search for dark matter produced with an energetic jet or a hadronically decaying W or Z boson at \sqrt{s}=13 TeV. JHEP, 2017, 07, pp.014. ⟨10.1007/JHEP07(2017)014⟩. ⟨hal-01669620⟩
    • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of the production cross section of the W boson in association with two b jets in pp collisions at sqrt(s) = 8 TeV. European Physical Journal C: Particles and Fields, 2017, 77, pp.92. ⟨10.1140/epjc/s10052-016-4573-z⟩. ⟨in2p3-01357547⟩
    • V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Jet energy scale and resolution in the CMS experiment in pp collisions at 8 TeV. Journal of Instrumentation, 2017, 12 (02), pp.P02014. ⟨10.1088/1748-0221/12/02/P02014⟩. ⟨in2p3-01346043⟩

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