Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • J. Adam, I. Belikov, J.C. Hamon, B. Hippolyte, C. Kuhn, et al.. Flow dominance and factorization of transverse momentum correlations in Pb-Pb collisions at the LHC. Physical Review Letters, 2017, 118, pp.162302. ⟨10.1103/PhysRevLett.118.162302⟩. ⟨in2p3-01464131⟩
  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Observation of charge-dependent azimuthal correlations in pPb collisions and its implication for the search for the chiral magnetic effect. Physical Review Letters, 2017, 118 (12), pp.122301. ⟨10.1103/PhysRevLett.118.122301⟩. ⟨in2p3-01376017⟩
  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for supersymmetry with multiple charged leptons in proton-proton collisions at sqrt(s) = 13 TeV. European Physical Journal C: Particles and Fields, 2017, 77, pp.635. ⟨10.1140/epjc/s10052-017-5182-1⟩. ⟨in2p3-01449457⟩
  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for CP violation in top quark-antiquark production and decay in proton-proton collisions at sqrt(s) = 8 TeV. Journal of High Energy Physics, 2017, 03 (3), pp.101. ⟨10.1007/JHEP03(2017)101⟩. ⟨in2p3-01404605⟩
  • A.M. Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Principal-component analysis of two-particle azimuthal correlations in PbPb and p\text{Pb} collisions at CMS. Physical Review C, 2017, 96 (6), pp.064902. ⟨10.1103/PhysRevC.96.064902⟩. ⟨hal-01669770⟩
  • Shreyasi Acharya, Dagmar Adamova, Jonatan Adolfsson, Madan Mohan Aggarwal, Gianluca Aglieri Rinella, et al.. Linear and non-linear flow modes in Pb-Pb collisions at \sqrt{s_{\rm NN}} = 2.76 TeV. Physics Letters B, 2017, 773, pp.68-80. ⟨10.1016/j.physletb.2017.07.060⟩. ⟨hal-01582582⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Ece Asilar, Thomas Bergauer, et al.. Search for black holes in high-multiplicity final states in proton-proton collisions at \sqrt{s}=13 TeV. Phys.Lett.B, 2017, 774, pp.279-307. ⟨10.1016/j.physletb.2017.09.053⟩. ⟨hal-01669576⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Ece Aşılar, Thomas Bergauer, et al.. Search for new physics with dijet angular distributions in proton-proton collisions at \sqrt{s}=13 TeV. JHEP, 2017, 07, pp.013. ⟨10.1007/JHEP07(2017)013⟩. ⟨hal-01669472⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Ece Aşılar, Thomas Bergauer, et al.. Search for dark matter produced with an energetic jet or a hadronically decaying W or Z boson at \sqrt{s}=13 TeV. JHEP, 2017, 07, pp.014. ⟨10.1007/JHEP07(2017)014⟩. ⟨hal-01669620⟩
  • Bogna Kubik, Noam I. Libeskind, Alexander Knebe, Hélène Courtois, Gustavo Yepes, et al.. Universal subhalo accretion in cold and warm dark matter cosmologies. Mon.Not.Roy.Astron.Soc., 2017, 472 (4), pp.4099-4109. ⟨10.1093/mnras/stx2263⟩. ⟨hal-01645726⟩

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