Health

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:

SAADE Gaëlle

8786 documents

Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Ece Aşılar, Thomas Bergauer, et al.. Search for third-generation scalar leptoquarks and heavy right-handed neutrinos in final states with two tau leptons and two jets in proton-proton collisions at $\sqrt{s}=13$ TeV. JHEP, 2017, 07, pp.121. ⟨10.1007/JHEP07(2017)121⟩. ⟨hal-01669784⟩
Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Ece Aşılar, Thomas Bergauer, et al.. Search for a heavy resonance decaying to a top quark and a vector-like top quark at $\sqrt{s}=13$ TeV. JHEP, 2017, 09, pp.053. ⟨10.1007/JHEP09(2017)053⟩. ⟨hal-01703563⟩
Vardan Khachatryan, Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Ece Aşılar, et al.. Measurement of the cross section for electroweak production of Z $\gamma$ in association with two jets and constraints on anomalous quartic gauge couplings in proton–proton collisions at $\sqrt{s} = 8$ TeV. Phys.Lett.B, 2017, 770, pp.380-402. ⟨10.1016/j.physletb.2017.04.071⟩. ⟨hal-01669817⟩
K. Abe, J. Amey, C. Andreopoulos, M. Antonova, S. Aoki, et al.. Updated T2K measurements of muon neutrino and antineutrino disappearance using 1.5 $\times$ 10 $^{21}$ protons on target. Phys.Rev.D, 2017, 96 (1), pp.011102. ⟨10.1103/PhysRevD.96.011102⟩. ⟨hal-01645237⟩
Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Ece Asilar, Thomas Bergauer, et al.. Measurement of the top quark mass in the dileptonic $t\bar{t}$ decay channel using the mass observables $M_{b\ell}$ , $M_{T2}$ , and $M_{b\ell\nu}$ in pp collisions at $\sqrt{s}=8$ TeV. Phys.Rev.D, 2017, 96 (3), pp.032002. ⟨10.1103/PhysRevD.96.032002⟩. ⟨hal-01669790⟩
D. Ralet, S. Pietri, T. Rodríguez, M. Alaqeel, T. Alexander, et al.. Lifetime measurement of neutron-rich even-even molybdenum isotopes. Physical Review C, 2017, 95 (3), pp.034320. ⟨10.1103/PhysRevC.95.034320⟩. ⟨hal-01554441⟩
M. Belabbas, J.J. Li, J. Margueron. Finite-temperature pairing re-entrance in the drip-line nucleus $^{48}\text{Ni}$ . Phys.Rev.C, 2017, 96 (2), pp.024304. ⟨10.1103/PhysRevC.96.024304⟩. ⟨hal-01582397⟩
V. Andreev, A. Baghdasaryan, K. Begzsuren, A. Belousov, V. Bertone, et al.. Determination of the strong coupling constant $\alpha_s(m_Z)$ in next-to-next-to-leading order QCD using H1 jet cross section measurements. Eur.Phys.J.C, 2017, 77 (11), pp.791. ⟨10.1140/epjc/s10052-017-5314-7⟩. ⟨hal-01669553⟩
S. Acharya, A. Baldisseri, H. Borel, J. Castillo Castellanos, J.L. Charvet, et al.. Measurement of D-meson production at mid-rapidity in pp collisions at $\mathbf{\sqrt{s}=7}$ TeV. European Physical Journal C: Particles and Fields, 2017, 77, pp.550. ⟨10.1140/epjc/s10052-017-5090-4⟩. ⟨in2p3-01454731⟩
Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Ece Asilar, Thomas Bergauer, et al.. Measurement of the ${B}^{\pm}$ Meson Nuclear Modification Factor in Pb-Pb Collisions at $\sqrt{{s}_{NN}}=5.02\text{ }\text{ }\mathrm{TeV}$ . Physical Review Letters, 2017, 119 (15), pp.152301. ⟨10.1103/PhysRevLett.119.152301⟩. ⟨hal-01669602⟩

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