Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • D. Adamova, A. Baldisseri, H. Borel, J. Castillo Castellanos, J.L. Charvet, et al.. Azimuthally differential pion femtoscopy in Pb-Pb collisions at \sqrt{s_{\rm NN}}=2.76 TeV. Physical Review Letters, 2017, 118, pp.222301. ⟨10.1103/PhysRevLett.118.222301⟩. ⟨in2p3-01458788⟩
  • K. Abe, J. Amey, C. Andreopoulos, M. Antonova, S. Aoki, et al.. Updated T2K measurements of muon neutrino and antineutrino disappearance using 1.5\times10^{21} protons on target. Phys.Rev.D, 2017, 96 (1), pp.011102. ⟨10.1103/PhysRevD.96.011102⟩. ⟨hal-01645237⟩
  • Vardan Khachatryan, Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Ece Aşılar, et al.. Measurement of the cross section for electroweak production of Z\gamma in association with two jets and constraints on anomalous quartic gauge couplings in proton–proton collisions at \sqrt{s} = 8 TeV. Phys.Lett.B, 2017, 770, pp.380-402. ⟨10.1016/j.physletb.2017.04.071⟩. ⟨hal-01669817⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Searches for W′ bosons decaying to a top quark and a bottom quark in proton-proton collisions at 13 TeV. JHEP, 2017, 08, pp.029. ⟨10.1007/JHEP08(2017)029⟩. ⟨hal-01669796⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Measurement of vector boson scattering and constraints on anomalous quartic couplings from events with four leptons and two jets in proton–proton collisions at \sqrt{s}= 13 TeV. Phys.Lett.B, 2017, 774, pp.682-705. ⟨10.1016/j.physletb.2017.10.020⟩. ⟨hal-01669814⟩
  • J. Adam, J.C. Hamon, B. Hippolyte, C. Kuhn, A. Maire, et al.. Centrality dependence of the pseudorapidity density distribution for charged particles in Pb-Pb collisions at \sqrt{s_{\rm NN}}=5.02 TeV. Physics Letters B, 2017, 772, pp.567-577. ⟨10.1016/j.physletb.2017.07.017⟩. ⟨in2p3-01425241⟩
  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for light bosons in decays of the 125 GeV Higgs boson in proton-proton collisions at sqrt(s) = 8 TeV. Journal of High Energy Physics, 2017, 10(2017) (10), pp.76. ⟨10.1007/JHEP10(2017)076⟩. ⟨in2p3-01430540⟩
  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of the transverse momentum spectra of weak vector bosons produced in proton-proton collisions at sqrt(s) = 8 TeV. Journal of High Energy Physics, 2017, 02 (2), pp.96. ⟨10.1007/JHEP02(2017)096⟩. ⟨in2p3-01334566⟩
  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurements of the differential production cross sections for a Z boson in association with jets in pp collisions at sqrt(s) = 8 TeV. Journal of High Energy Physics, 2017, 04 (4), pp.022. ⟨10.1007/JHEP04(2017)022⟩. ⟨in2p3-01396129⟩
  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurements of the associated production of a Z boson and b jets in pp collisions at sqrt(s) = 8 TeV. European Physical Journal C: Particles and Fields, 2017, 77, pp.751. ⟨10.1140/epjc/s10052-017-5140-y⟩. ⟨in2p3-01400577⟩

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