Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

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- DOCTORANTS / DOCTORAL STUDENTS:
    8790 documents

    • Armen Tumasyan, Wolfgang Adam, Janik Walter Andrejkovic, Thomas Bergauer, Suman Chatterjee, et al.. Search for a heavy Higgs boson decaying into two lighter Higgs bosons in the \tau\taubb final state at 13 TeV. JHEP, 2021, 11, pp.057. ⟨10.1007/JHEP11(2021)057⟩. ⟨hal-03280753⟩
    • Armen Tumasyan, Wolfgang Adam, Janik Walter Andrejkovic, Thomas Bergauer, Suman Chatterjee, et al.. Measurement of the inclusive and differential t\overline{t}γ cross sections in the single-lepton channel and EFT interpretation at \sqrt{s} = 13 TeV. JHEP, 2021, 12, pp.180. ⟨10.1007/JHEP12(2021)180⟩. ⟨hal-03504883⟩
    • Wafa Bouleftour, Elise Rowinski, Safa Louati, Sandrine Sotton, Anne-Sophie Wozny, et al.. A Review of the Role of Hypoxia in Radioresistance in Cancer Therapy. Medical Science Monitor, 2021, 27, pp.e934116. ⟨10.12659/msm.934116⟩. ⟨hal-03450007⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Thomas Bergauer, Marko Dragicevic, et al.. Search for nonresonant Higgs boson pair production in final states with two bottom quarks and two photons in proton-proton collisions at \sqrt{s} = 13 TeV. JHEP, 2021, 03, pp.257. ⟨10.1007/JHEP03(2021)257⟩. ⟨hal-03070698⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Evidence for electroweak production of four charged leptons and two jets in proton-proton collisions at \sqrt {s} = 13 TeV. Phys.Lett.B, 2021, 812, pp.135992. ⟨10.1016/j.physletb.2020.135992⟩. ⟨hal-02934053⟩
    • Armen Tumasyan, Wolfgang Adam, Janik Walter Andrejkovic, Thomas Bergauer, Suman Chatterjee, et al.. Measurements of the electroweak diboson production cross sections in proton-proton collisions at \sqrt{s} = 5.02 TeV using leptonic decays. Phys.Rev.Lett., 2021, 127 (19), pp.191801. ⟨10.1103/PhysRevLett.127.191801⟩. ⟨hal-03413867⟩
    • R. Abbott, T.D. Abbott, S. Abraham, F. Acernese, K. Ackley, et al.. Constraints from LIGO O3 Data on Gravitational-wave Emission Due to R-modes in the Glitching Pulsar PSR J0537–6910. Astrophys.J., 2021, 922 (1), pp.71. ⟨10.3847/1538-4357/ac0d52⟩. ⟨hal-03224757⟩
    • Rashmi Kumar, Hui Xiao Chao, Dennis Simpson, Wanjuan Feng, Min-Guk Cho, et al.. Dual inhibition of DNA-PK and DNA polymerase theta overcomes radiation resistance induced by p53 deficiency. NAR Cancer, 2020, 2 (4), ⟨10.1093/narcan/zcaa038⟩. ⟨hal-03133102⟩
    • Michael Beuve. NanOx, a new multiscale model to predict biological dose for hadrontherapy. 6th International Virtual Conference on Ion Beams in Materials Engineering and Characterizations (IBMEC 2020), Dec 2020, New Delhi (Virtual), India. ⟨hal-03258217⟩
    • Nils Krah, Catherine Therese T Quiñones, Jean-Michel Létang, Simon Rit. Scattering proton CT. Physics in Medicine and Biology, 2020, 65 (22), pp.225015. ⟨10.1088/1361-6560/abbd18⟩. ⟨hal-02959263⟩

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