Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:

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8785 documents

  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Thomas Bergauer, Marko Dragicevic, et al.. Search for dark matter produced in association with a leptonically decaying Z boson in proton-proton collisions at \sqrt{s} = 13 TeV. Eur.Phys.J.C, 2021, 81 (1), pp.13. ⟨10.1140/epjc/s10052-020-08739-5⟩. ⟨hal-02934005⟩
  • Rashmi Kumar, Hui Xiao Chao, Dennis Simpson, Wanjuan Feng, Min-Guk Cho, et al.. Dual inhibition of DNA-PK and DNA polymerase theta overcomes radiation resistance induced by p53 deficiency. NAR Cancer, 2020, 2 (4), ⟨10.1093/narcan/zcaa038⟩. ⟨hal-03133102⟩
  • Michael Beuve. NanOx, a new multiscale model to predict biological dose for hadrontherapy. 6th International Virtual Conference on Ion Beams in Materials Engineering and Characterizations (IBMEC 2020), Dec 2020, New Delhi (Virtual), India. ⟨hal-03258217⟩
  • Nils Krah, Catherine Therese T Quiñones, Jean-Michel Létang, Simon Rit. Scattering proton CT. Physics in Medicine and Biology, 2020, 65 (22), pp.225015. ⟨10.1088/1361-6560/abbd18⟩. ⟨hal-02959263⟩
  • M.-L. Gallin-Martel, Oreste Allegrini, A. Bes, G. Bosson, J. P. Cachemiche, et al.. Etiquetage spatio-temporel et monitorage de faisceaux pulsés : applications en hadronthérapie et thérapies « flash ». Journée d'échanges scientifiques GDR MI2B ARCHADE, Nov 2020, Virtuel, France. ⟨hal-03159394⟩
  • A. Etxebeste, Denis Dauvergne, Jean Michel Létang, M. Borja-Lloret, G. Llosá, et al.. Compton camera design optimization for detection efficiency enhancement in Nuclear Medicine. IEEE Nuclear Science Symposium and Medical Imaging Conference (IEEE NSS MIC) 2020, Oct 2020, Virtual Boston, United States. ⟨hal-03129834⟩
  • Marie-Laure Gallin-Martel, A. Bes, G. Bosson, J. Bouvier, J. Collot, et al.. Diamond-based detector development for pulsed beam monitoring for medical applications. Very High Energy Electron Radiotherapy Workshop (VHEE2020), CERN, Oct 2020, Meyrin, Switzerland. ⟨hal-03157968⟩
  • Riad Ladjohounlou, Safa Louati, Alexandra Lauret, Arnaud Gauthier, Dominique Ardail, et al.. Ceramide-Enriched Membrane Domains Contribute to Targeted and Nontargeted Effects of Radiation through Modulation of PI3K/AKT Signaling in HNSCC Cells. International Journal of Molecular Sciences, 2020, 21 (19), pp.7200. ⟨10.3390/ijms21197200⟩. ⟨hal-03001763⟩
  • A. Blanchard, S. Camera, C. Carbone, V. F. Cardone, S. Casas, et al.. Euclid preparation. VII. Forecast validation for Euclid cosmological probes. Astronomy & Astrophysics - A&A, 2020, 642, pp.A191. ⟨10.1051/0004-6361/202038071⟩. ⟨hal-02976446⟩
  • Janina Kopyra, Franck Rabilloud, Hassan Abdoul-Carime. Decomposition of Bis(acetylacetonate)zinc(II) by Slow Electrons. Inorganic Chemistry, 2020, 59 (17), pp.12788-12792. ⟨10.1021/acs.inorgchem.0c01842⟩. ⟨hal-02941349⟩

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