Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • B. Trzeciak, C. da Silva, E.G. Ferreiro, C. Hadjidakis, D. Kikola, et al.. Heavy-ion Physics at a Fixed-Target Experiment Using the LHC Proton and Lead Beams (AFTER@LHC): Feasibility Studies for Quarkonium and Drell-Yan Production. Few Body Syst., 2017, 58 (5), pp.148. ⟨10.1007/s00601-017-1308-0⟩. ⟨hal-01582735⟩
  • S. Hohenegger, S. Stieberger. Monodromy Relations in Higher-Loop String Amplitudes. Nuclear Physics B, 2017, 925, pp.63-134. ⟨10.1016/j.nuclphysb.2017.09.020⟩. ⟨in2p3-01470087⟩
  • Chloé Rancoule, Alexis Vallard, Jean-Baptiste Guy, Sophie Espenel, Peng Diao, et al.. Brain metastases from non-small cell lung carcinoma: Changing concepts for improving patients’ outcome. Crit.Rev.Oncol.Hematol., 2017, 116, pp.32-37. ⟨10.1016/j.critrevonc.2017.05.007⟩. ⟨hal-02404404⟩
  • M. Venhart, F.A. Ali, W. Ryssens, J.L. Wood, D.T. Joss, et al.. De-excitation of the strongly coupled band in ^{177}Au and implications for core intruder configurations in the light Hg isotopes. Phys.Rev.C, 2017, 95 (6), pp.061302. ⟨10.1103/PhysRevC.95.061302⟩. ⟨hal-01554898⟩
  • Daniel Pomarede, Yehuda Hoffman, Helene M Courtois, R. Brent Tully. The Cosmic V-Web. The Astrophysical Journal, 2017, 845 (1), pp.55. ⟨10.3847/1538-4357/aa7f78⟩. ⟨hal-01582416⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Ece Asilar, Thomas Bergauer, et al.. Measurement of charged pion, kaon, and proton production in proton-proton collisions at \sqrt{s}=13 TeV. Physical Review D, 2017, 96 (11), pp.112003. ⟨10.1103/PhysRevD.96.112003⟩. ⟨hal-01669810⟩
  • P. Becker, D. Davesne, J. Meyer, J. Navarro, A. Pastore. Solution of Hartree-Fock-Bogoliubov equations and fitting procedure using the N2LO Skyrme pseudopotential in spherical symmetry. Phys.Rev.C, 2017, 96 (4), pp.044330. ⟨10.1103/PhysRevC.96.044330⟩. ⟨hal-01645853⟩
  • N. Lesparre, Justo Cabrera, J. Marteau. 3-D density imaging with muon flux measurements from underground galleries. Geophys.J.Int., 2017, 208 (3), pp.1579-1591. ⟨10.1093/gji/ggw482⟩. ⟨hal-01922035⟩
  • Marina Rosas-Carbajal, Kevin Jourde, Jacques Marteau, Sebastien Deroussi, Jean-Christophe Komorowski, et al.. Three-dimensional density structure of La Soufrière de Guadeloupe lava dome from simultaneous muon radiographies and gravity data. Geophysical Research Letters, 2017, 44 (13), pp.6743-6751. ⟨10.1002/2017GL074285⟩. ⟨insu-01561114⟩
  • G. Aarts, Joerg Aichelin, C. Allton, R. Arnaldi, S. A. Bass, et al.. Heavy-flavor production and medium properties in high-energy nuclear collisions - What next?. The European physical journal. A, Hadrons and Nuclei, 2017, 53 (5), pp.93. ⟨10.1140/epja/i2017-12282-9⟩. ⟨in2p3-01424872⟩

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