Health (PRISME)

  • Presentation
  • Activities
  • Members
  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • C. Ray, D. Dauvergne. Proton and light ion deflection at medium energies with planar bent crystals. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2017, 402, pp.313-320. ⟨10.1016/j.nimb.2017.02.078⟩. ⟨in2p3-01544722⟩
  • M. Gouzevitch. Some though about the choice of MVA variables for HH. HH searches with CMS, Jan 2017, Louvain-La-Neuve, Belgium. ⟨hal-02076934⟩
  • A Farhaoui, A Bousquet, Rafik Smaali, A Moreau, E Centeno, et al.. Reactive gas pulsing sputtering process, a promising technique to elaborate silicon oxynitride multilayer nanometric antireflective coatings. Journal of Physics D: Applied Physics, 2017, 50, ⟨10.1088/1361-6463/50/1/015306⟩. ⟨hal-04287139⟩
  • Benjamin P. Abbott, Rich Abbott, Thomas D. Abbott, Fausto Acernese, Kendall Ackley, et al.. Search for gravitational waves from Scorpius X-1 in the first Advanced LIGO observing run with a hidden Markov model. Phys.Rev.D, 2017, 95 (12), pp.122003. ⟨10.1103/PhysRevD.95.122003⟩. ⟨hal-02485091⟩
  • A. Arbey, G. Cacciapaglia, H. Cai, A. Deandrea, S. Le Corre, et al.. Fundamental Composite Electroweak Dynamics: Status at the LHC. Physical Review D, 2017, 95, pp.015028. ⟨10.1103/PhysRevD.95.015028⟩. ⟨in2p3-01126699⟩
  • C. Aidala, N.N. Ajitanand, Y. Akiba, R. Akimoto, J. Alexander, et al.. Cross section and transverse single-spin asymmetry of muons from open heavy-flavor decays in polarized p+p collisions at \sqrt{s}=200 GeV. Phys.Rev.D, 2017, 95 (11), pp.112001. ⟨10.1103/PhysRevD.95.112001⟩. ⟨hal-01582918⟩
  • Martín González-Alonso, Jorge Martin Camalich, Kin Mimouni. Renormalization-group evolution of new physics contributions to (semi)leptonic meson decays. Physics Letters B, 2017, 772, pp.777-785. ⟨10.1016/j.physletb.2017.07.003⟩. ⟨hal-01645691⟩
  • A. Ruciński, J. Gajewski, P. Olko, I. Rinaldi, V. Patera, et al.. GPU-accelerated Monte Carlo Code for Fast Dose Recalculation in Proton Beam Therapy. Acta Phys.Polon.B, 2017, 48 (10), pp.1625. ⟨10.5506/APhysPolB.48.1625⟩. ⟨hal-01703703⟩
  • S. Aghion, C. Amsler, A. Ariga, T. Ariga, G. Bonomi, et al.. Measurement of antiproton annihilation on Cu, Ag and Au with emulsion films. Journal of Instrumentation, 2017, 12 (04), pp.P04021. ⟨10.1088/1748-0221/12/04/P04021⟩. ⟨in2p3-01468508⟩
  • A. Ribar, K. Fink, Z. Li, S. Ptasińska, I. Carmichael, et al.. Stripping off hydrogens in imidazole triggered by the attachment of a single electron. Phys.Chem.Chem.Phys., 2017, 19 (9), pp.6406-6415. ⟨10.1039/C6CP08773F⟩. ⟨hal-01555153⟩

Powered by HAL logo