Health (PRISME)
- Presentation
- Activities
- Members
- Publications
The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.
Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.
One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.
The activities can be divided into three research areas:
Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.
Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.
Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.
NON-PERMANENTS:
- DOCTORANTS / DOCTORAL STUDENTS:
- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
- V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for narrow resonances in dilepton mass spectra in proton-proton collisions at sqrt(s) = 13 TeV and combination with 8 TeV data. Physics Letters B, 2017, 768, pp.57-80. ⟨10.1016/j.physletb.2017.02.010⟩. ⟨in2p3-01368773⟩
- A.M. Sirunyan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Searches for pair production for third-generation squarks in sqrt(s)=13 TeV pp collisions. European Physical Journal C: Particles and Fields, 2017, 77, pp.327. ⟨10.1140/epjc/s10052-017-4853-2⟩. ⟨in2p3-01415369⟩
- V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. A search for new phenomena in pp collisions at sqrt(s) = 13 TeV in final states with missing transverse momentum and at least one jet using the alphaT variable. European Physical Journal C: Particles and Fields, 2017, 77, pp.294. ⟨10.1140/epjc/s10052-017-4787-8⟩. ⟨in2p3-01390465⟩
- Brice Bastian, Stefan Hohenegger. Five-Brane Webs and Highest Weight Representations. Journal of High Energy Physics, 2017, 12, pp.020. ⟨10.1007/JHEP12(2017)020⟩. ⟨hal-01669730⟩
- B. Souères, D. Tsimpis. The action principle and the supersymmetrisation of Chern-Simons terms in eleven-dimensional supergravity. Physical Review D, 2017, 95, pp.026013. ⟨10.1103/PhysRevD.95.026013⟩. ⟨in2p3-01420764⟩
- L.A.P. Zayas, D. Tsimpis, C.A. Whiting. A Supersymmetric IIB Background with AdS_4 from Massive IIA. Physical Review D, 2017, 96, pp.046013. ⟨10.1103/PhysRevD.96.046013⟩. ⟨in2p3-01430545⟩
- A. Arbey, M. Boudaud, F. Mahmoudi, G. Robbins. Robustness of dark matter constraints and interplay with collider searches for New Physics. Journal of High Energy Physics, 2017, 11, pp.132. ⟨10.1007/JHEP11(2017)132⟩. ⟨hal-01669715⟩
- H. Gómez, C. Goy, Y. Karyotakis, S. Katsanevas, J. Marteau, et al.. Forward scattering effects on muon imaging. Journal of Instrumentation, 2017, 12 (12), pp.P12018. ⟨10.1088/1748-0221/12/12/P12018⟩. ⟨hal-01669806⟩
- K. Abe, C. Andreopoulos, M. Antonova, S. Aoki, A. Ariga, et al.. First Measurement of the Muon Neutrino Charged Current Single Pion Production Cross Section on Water with the T2K Near Detector. Physical Review D, 2017, 95, pp.012010. ⟨10.1103/PhysRevD.95.012010⟩. ⟨in2p3-01321555⟩
- M. Régis, J. Jolie, N. Saed-Samii, N. Warr, M. Pfeiffer, et al.. Abrupt shape transition at neutron number N = 60 : B ( E 2 ) values in
Sr from fast 
timing. Physical Review C, 2017, 95 (5), pp.054319. ⟨10.1103/PhysRevC.95.054319⟩. ⟨in2p3-01528896⟩
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