Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for direct production of supersymmetric partners of the top quark in the all-jets final state in proton-proton collisions at \sqrt{s}=13 TeV. JHEP, 2017, 10, pp.005. ⟨10.1007/JHEP10(2017)005⟩. ⟨hal-01669718⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Ece Aşılar, Thomas Bergauer, et al.. Search for anomalous couplings in boosted \mathrm{ WW/WZ }\to\ell\nu\mathrm{ q \bar{q} } production in proton-proton collisions at \sqrt{s} = 8 TeV. Phys.Lett.B, 2017, 772, pp.21-42. ⟨10.1016/j.physletb.2017.06.009⟩. ⟨hal-01669464⟩
  • Shreyasi Acharya, Dagmar Adamova, Jonatan Adolfsson, Madan Mohan Aggarwal, Gianluca Aglieri Rinella, et al.. Searches for transverse momentum dependent flow vector fluctuations in Pb-Pb and p-Pb collisions at the LHC. Journal of High Energy Physics, 2017, 09, pp.032. ⟨10.1007/JHEP09(2017)032⟩. ⟨hal-01645744⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Ece Asilar, Thomas Bergauer, et al.. Search for top quark partners with charge 5/3 in proton-proton collisions at \sqrt{s}=13 TeV. JHEP, 2017, 08, pp.073. ⟨10.1007/JHEP08(2017)073⟩. ⟨hal-01704427⟩
  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. A search for new phenomena in pp collisions at sqrt(s) = 13 TeV in final states with missing transverse momentum and at least one jet using the alphaT variable. European Physical Journal C: Particles and Fields, 2017, 77, pp.294. ⟨10.1140/epjc/s10052-017-4787-8⟩. ⟨in2p3-01390465⟩
  • J. Hartley, L. L. Riedinger, V. Janssens, S. Majola, M. A. Riley, et al.. Investigation of negative-parity states in Dy 156 : Search for evidence of tetrahedral symmetry. Physical Review C, 2017, 95 (1), pp.014321. ⟨10.1103/PhysRevC.95.014321⟩. ⟨in2p3-01449514⟩
  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement and QCD analysis of double-differential inclusive jet cross-sections in pp collisions at sqrt(s) = 8 TeV and ratios to 2.76 and 7 TeV. Journal of High Energy Physics, 2017, 03 (3), pp.156. ⟨10.1007/JHEP03(2017)156⟩. ⟨in2p3-01368771⟩
  • A.M. Sirunyan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for high-mass Z gamma resonances at sqrt(s) = 8 and 13 TeV using jet substructure techniques. Physics Letters B, 2017, 772, pp.363-387. ⟨10.1016/j.physletb.2017.06.062⟩. ⟨in2p3-01424245⟩
  • A.M. Sirunyan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Searches for pair production for third-generation squarks in sqrt(s)=13 TeV pp collisions. European Physical Journal C: Particles and Fields, 2017, 77, pp.327. ⟨10.1140/epjc/s10052-017-4853-2⟩. ⟨in2p3-01415369⟩
  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for narrow resonances in dilepton mass spectra in proton-proton collisions at sqrt(s) = 13 TeV and combination with 8 TeV data. Physics Letters B, 2017, 768, pp.57-80. ⟨10.1016/j.physletb.2017.02.010⟩. ⟨in2p3-01368773⟩

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