Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • C. Monini, É. Testa, M. Beuve. NanOx Predictions of Cell Survival Probabilities for Three Cell Lines. Acta Phys.Polon.B, 2017, 48 (10), pp.1653. ⟨10.5506/APhysPolB.48.1653⟩. ⟨hal-01719459⟩
    • Shreyasi Acharya, Dagmar Adamova, Jonatan Adolfsson, Madan Mohan Aggarwal, Gianluca Aglieri Rinella, et al.. J/\psi elliptic flow in Pb-Pb collisions at \sqrt{s_\mathrm{NN}}=5.02 TeV. Phys.Rev.Lett., 2017, 119 (24), pp.242301. ⟨10.1103/PhysRevLett.119.242301⟩. ⟨hal-01669832⟩
    • Anita Ribar, Katharina Fink, Michael Probst, Stefan E. Huber, Linda Feketeová, et al.. Isomer Selectivity in Low-Energy Electron Attachment to Nitroimidazoles. Chemistry – A European Journal, 2017, 23 (52), pp.12892-12899. ⟨10.1002/chem.201702644⟩. ⟨hal-01768117⟩
    • Victor Mukhamedovich Abazov, Braden Keim Abbott, Bannanje Sripath Acharya, Mark Raymond Adams, Todd Adams, et al.. Combination of D0 measurements of the top quark mass. Phys.Rev.D, 2017, 95 (11), pp.112004. ⟨10.1103/PhysRevD.95.112004⟩. ⟨hal-01554693⟩
    • A. Korichi, T. Lauritsen, A.N. Wilson, J. Dudouet, E. ClĂ©ment, et al.. Performance of a gamma-ray tracking array: Characterizing the AGATA array using a 60Co source. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2017, 872, pp.60039. ⟨10.1016/j.nima.2017.08.020⟩. ⟨hal-01645783⟩
    • D. Ralet, G. Georgiev, A. E. Stuchbery, E. ClĂ©ment, A. Lemasson, et al.. Toward lifetime and g factor measurements of short-lived states in the vicinity of ^{208}Pb. Physica Scripta, 2017, 92 (5), pp.054004. ⟨10.1088/1402-4896/aa6942⟩. ⟨hal-01554700⟩
    • Vincenzo Cirigliano, Sacha Davidson, Yoshitaka Kuno. Spin-dependent \mu \to e conversion. Physics Letters B, 2017, 771, pp.242-246. ⟨10.1016/j.physletb.2017.05.053⟩. ⟨hal-01554923⟩
    • S. Aghion, C. Amsler, T. Ariga, G. Bonomi, R.S. Brusa, et al.. Characterization of a transmission positron/positronium converter for antihydrogen production. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2017, 407, pp.55-66. ⟨10.1016/j.nimb.2017.05.059⟩. ⟨hal-01554901⟩
    • Nicolas Deutschmann, Claude Duhr, Fabio Maltoni, Eleni Vryonidou. Gluon-fusion Higgs production in the Standard Model Effective Field Theory. Journal of High Energy Physics, 2017, 12, pp.063. ⟨10.1007/JHEP12(2017)063⟩. ⟨hal-01704888⟩
    • A. Arbey, M. Boudaud, F. Mahmoudi, G. Robbins. Robustness of dark matter constraints and interplay with collider searches for New Physics. Journal of High Energy Physics, 2017, 11, pp.132. ⟨10.1007/JHEP11(2017)132⟩. ⟨hal-01669715⟩

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