Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • Michael Beuve. Biophysics Modeling to Optimize Ion Beam Cancer Therapy. Nanoscale Insights into Ion-Beam Cancer Therapy, Springer International Publishing Switzerland, pp.435-465, 2017, ⟨10.1007/978-3-319-43030-0_13⟩. ⟨hal-01458953⟩
    • A.M. Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for pair production of vector-like T and B quarks in single-lepton final states using boosted jet substructure in proton-proton collisions at \sqrt{s}=13 TeV. JHEP, 2017, 11, pp.085. ⟨10.1007/JHEP11(2017)085⟩. ⟨hal-01704864⟩
    • A.M. Sirunyan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for massive resonances decaying into WW, WZ or ZZ bosons in proton-proton collisions at sqrt(s) = 13 TeV. Journal of High Energy Physics, 2017, 03 (3), pp.162. ⟨10.1007/JHEP03(2017)162⟩. ⟨in2p3-01424867⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Measurement of the differential cross sections for the associated production of a W boson and jets in proton-proton collisions at \sqrt{s}=13 TeV. Phys.Rev.D, 2017, 96 (7), pp.072005. ⟨10.1103/PhysRevD.96.072005⟩. ⟨hal-01669585⟩
    • A.M. Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for a heavy composite Majorana neutrino in the final state with two leptons and two quarks at \sqrt{s}=13 TeV. Phys.Lett.B, 2017, 775, pp.315-337. ⟨10.1016/j.physletb.2017.11.001⟩. ⟨hal-01669765⟩
    • A.M. Sirunyan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for dark matter and unparticles in events with a Z boson and missing transverse momentum in proton-proton collisions at sqrt(s) = 13 TeV. Journal of High Energy Physics, 2017, 03(2017) (3), pp.061. ⟨10.1007/JHEP03(2017)061⟩. ⟨in2p3-01430542⟩
    • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. The CMS trigger system. Journal of Instrumentation, 2017, 12 (01), pp.P01020. ⟨10.1088/1748-0221/12/01/P01020⟩. ⟨in2p3-01362517⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for Evidence of the Type-III Seesaw Mechanism in Multilepton Final States in Proton-Proton Collisions at \sqrt{s}=13\text{ }\text{ }\mathrm{TeV}. Phys.Rev.Lett., 2017, 119 (22), pp.221802. ⟨10.1103/PhysRevLett.119.221802⟩. ⟨hal-01669772⟩
    • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of inclusive jet cross-sections in pp and PbPb collisions at sqrt(s[NN])=2.76 TeV. Physical Review C, 2017, 96, pp.015202. ⟨10.1103/PhysRevC.96.015202⟩. ⟨in2p3-01368772⟩
    • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for high-mass diphoton resonances in proton-proton collisions at 13 TeV and combination with 8 TeV search. Physics Letters B, 2017, 767, pp.147-170. ⟨10.1016/j.physletb.2017.01.027⟩. ⟨in2p3-01362519⟩

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