Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • T. Hurth, F. Mahmoudi, D. Martinez Santos, S. Neshatpour. Lepton nonuniversality in exclusive b{\rightarrow}s{\ell}{\ell} decays. Physical Review D, 2017, 96 (9), pp.095034. ⟨10.1103/PhysRevD.96.095034⟩. ⟨hal-01669709⟩
  • C. Aidala, Y. Akiba, M. Alfred, K. Aoki, N. Apadula, et al.. Measurements of azimuthal anisotropy and charged-particle multiplicity in d+Au collisions at \sqrt{s_{_{NN}}}=200, 62.4, 39, and 19.6 GeV. Phys.Rev.C, 2017, 96 (6), pp.064905. ⟨10.1103/PhysRevC.96.064905⟩. ⟨hal-01703661⟩
  • Jean-Pierre Cussonneau, J M Abaline, S. Acounis, N. Beaupere, J L Beney, et al.. 3gamma medical imaging with a liquid xenon Compton Camera and 44Sc radionuclide. Acta Physica Polonica B, 2017, 48 (10), ⟨10.5506/APhysPolB.48.1661⟩. ⟨inserm-01635537⟩
  • Benoîte Méry, Chloé Rancoule, Jean-Baptiste Guy, Sophie Espenel, Anne-Sophie Wozny, et al.. Preclinical models in HNSCC: A comprehensive review. Oral Oncology, 2017, 65, pp.51-56 ⟨10.1016/j.oraloncology.2016.12.010⟩. ⟨hal-01452979⟩
  • J. Billard, R. Carr, J. Dawson, E. Figueroa-Feliciano, J.A. Formaggio, et al.. Coherent neutrino scattering with low temperature bolometers at Chooz reactor complex. J.Phys.G, 2017, 44 (10), pp.105101. ⟨10.1088/1361-6471/aa83d0⟩. ⟨hal-01645440⟩
  • J. Adam, Laurent Aphecetche, B. Audurier, A. Baldisseri, Guillaume Batigne, et al.. Measurement of the production of high-p_{\rm T} electrons from heavy-flavour hadron decays in Pb-Pb collisions at \mathbf{\sqrt{\it s_{\rm{NN}}}} = 2.76 TeV. Physics Letters B, 2017, 771, pp.467-481. ⟨10.1016/j.physletb.2017.05.060⟩. ⟨in2p3-01370611⟩
  • A.M. Sirunyan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Azimuthal anisotropy of charged particles with transverse momentum up to 100 GeV in PbPb collisions at sqrt(s[NN]) = 5.02 TeV. Physics Letters B, 2017, 776, pp.195. ⟨10.1016/j.physletb.2017.11.041⟩. ⟨in2p3-01454724⟩
  • J. Adam, Laurent Aphecetche, B. Audurier, A. Baldisseri, Guillaume Batigne, et al.. K^{*}(892)^{0} and \phi(1020) meson production at high transverse momentum in pp and Pb-Pb collisions at \sqrt{s_\mathrm{NN}} = 2.76 TeV. Physical Review C, 2017, 95, pp. 064606. ⟨10.1103/PhysRevC.95.064606⟩. ⟨in2p3-01454728⟩
  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of the total and differential inclusive B(+) hadron cross sections in pp collisions at sqrt(s) = 13 TeV. Physics Letters B, 2017, 771, pp.435. ⟨10.1016/j.physletb.2017.05.074⟩. ⟨in2p3-01360531⟩
  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurements of differential cross sections for associated production of a W boson and jets in proton-proton collisions at sqrt(s)=8 TeV. Physical Review D, 2017, 95, pp.052002. ⟨10.1103/PhysRevD.95.052002⟩. ⟨in2p3-01381107⟩

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