Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • Jaroslav Adam, Dagmar Adamova, Madan Mohan Aggarwal, Gianluca Aglieri Rinella, Michelangelo Agnello, et al.. Enhanced production of multi-strange hadrons in high-multiplicity proton-proton collisions. Nature Physics, 2017, 13, pp.535-539. ⟨10.1038/nphys4111⟩. ⟨hal-01703781⟩
  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Observation of Upsilon(1S) pair production in proton-proton collisions at sqrt(s) = 8 TeV. Journal of High Energy Physics, 2017, 05, pp.013. ⟨10.1007/JHEP05(2017)013⟩. ⟨in2p3-01387006⟩
  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for top squark pair production in compressed-mass-spectrum scenarios in proton-proton collisions at sqrt(s) = 8 TeV using the alphaT variable. Physics Letters B, 2017, 767, pp.403-430. ⟨10.1016/j.physletb.2017.02.007⟩. ⟨in2p3-01323688⟩
  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Suppression and azimuthal anisotropy of prompt and nonprompt J/psi production in PbPb collisions at sqrt(s[NN]) = 2.76 TeV. European Physical Journal C: Particles and Fields, 2017, 77, pp.252. ⟨10.1140/epjc/s10052-017-4781-1⟩. ⟨in2p3-01376026⟩
  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Pseudorapidity dependence of long-range two-particle correlations in pPb collisions at sqrt(s[NN])=5.02 TeV. Physical Review C, 2017, 96, pp.014915. ⟨10.1103/PhysRevC.96.014915⟩. ⟨in2p3-01304604⟩
  • A.M. Sirunyan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Study of jet quenching with Z+jet correlations in PbPb and pp collisions at sqrt(s[NN]) = 5.02 TeV. Physical Review Letters, 2017, 119, pp.082301. ⟨10.1103/PhysRevLett.119.082301⟩. ⟨in2p3-01456783⟩
  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of the ttbbar production cross section using events in the e mu final state in pp collisions at sqrt(s)=13 TeV. European Physical Journal C: Particles and Fields, 2017, 77, pp.172. ⟨10.1140/epjc/s10052-017-4718-8⟩. ⟨in2p3-01396812⟩
  • V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for new physics in events with high jet multiplicity and low missing transverse momentum in proton-proton collisions at sqrt(s) = 8 TeV. Physics Letters B, 2017, 770, pp.257. ⟨10.1016/j.physletb.2017.01.073⟩. ⟨in2p3-01351564⟩
  • T. Hurth, C. Langenbruch, F. Mahmoudi. Direct determination of Wilson coefficients using B^0\to K^{*0}\mu^+\mu^- decays. Journal of High Energy Physics, 2017, 11, pp.176. ⟨10.1007/JHEP11(2017)176⟩. ⟨hal-01703742⟩
  • Mattia Fontana, Denis Dauvergne, Jean Michel Létang, Jean-Luc Ley, Etienne Testa. Compton camera study for high efficiency SPECT and benchmark with Anger system. Physics in Medicine and Biology, 2017, 62, pp.8794-8812. ⟨10.1088/1361-6560/aa926a⟩. ⟨hal-01685468⟩

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