Health (PRISME)
- Presentation
- Activities
- Members
- Publications
The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.
Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.
One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.
The activities can be divided into three research areas:
Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.
Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.
Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.
NON-PERMANENTS:
- DOCTORANTS / DOCTORAL STUDENTS:
- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
- Armen Tumasyan, Wolfgang Adam, Janik Walter Andrejkovic, Thomas Bergauer, Suman Chatterjee, et al.. Measurements of the pp
W
and pp Z
cross sections at 
13 TeV and limits on anomalous quartic gauge couplings. JHEP, 2021, 10, pp.174. ⟨10.1007/JHEP10(2021)174⟩. ⟨hal-03261352⟩ - Nicolas Magné, Igor Latorzeff. Oligometastatic renal cell carcinoma: radiotherapy as a new standard of care?. Lancet Oncology, 2021, 22 (12), pp.1644-1645. ⟨10.1016/s1470-2045(21)00665-3⟩. ⟨hal-03507607⟩
- Armen Tumasyan, Wolfgang Adam, Janik Walter Andrejkovic, Thomas Bergauer, Suman Chatterjee, et al.. Measurement of the electroweak production of Z
and two jets in proton-proton collisions at 13 TeV and constraints on anomalous quartic gauge couplings. Phys.Rev.D, 2021, 104, pp.072001. ⟨10.1103/PhysRevD.104.072001⟩. ⟨hal-03280754⟩ - Nils Krah, Denis Dauvergne, Jean Michel Létang, Simon Rit, Etienne Testa. Energy-adaptive calculation of the most likely path in proton CT. Physics in Medicine and Biology, 2021, 66, pp.20NT02. ⟨10.1088/1361-6560/ac2999⟩. ⟨hal-03353954⟩
- Wafa Bouleftour, Elise Rowinski, Safa Louati, Sandrine Sotton, Anne-Sophie Wozny, et al.. A Review of the Role of Hypoxia in Radioresistance in Cancer Therapy. Medical Science Monitor, 2021, 27, pp.e934116. ⟨10.12659/msm.934116⟩. ⟨hal-03450007⟩
- Armen Tumasyan, Wolfgang Adam, Janik Walter Andrejkovic, Thomas Bergauer, Suman Chatterjee, et al.. Search for a heavy Higgs boson decaying into two lighter Higgs bosons in the
bb final state at 13 TeV. JHEP, 2021, 11, pp.057. ⟨10.1007/JHEP11(2021)057⟩. ⟨hal-03280753⟩ - Armen Tumasyan, Wolfgang Adam, Janik Walter Andrejkovic, Thomas Bergauer, Suman Chatterjee, et al.. Measurement of the inclusive and differential t
γ cross sections in the single-lepton channel and EFT interpretation at 
= 13 TeV. JHEP, 2021, 12, pp.180. ⟨10.1007/JHEP12(2021)180⟩. ⟨hal-03504883⟩ - Armen Tumasyan, Wolfgang Adam, Janik Walter Andrejkovic, Thomas Bergauer, Suman Chatterjee, et al.. Measurements of the electroweak diboson production cross sections in proton-proton collisions at 5.02 TeV using leptonic decays. Physical Review Letters, 2021, 127 (19), pp.191801. ⟨10.1103/PhysRevLett.127.191801⟩. ⟨hal-03413867⟩
- Ricardo Ramos, Floriane Poignant, Chen-Hui Chan, A. Ipatov, B. Gervais, et al.. Low-energy electron transport in gold: mesoscopic potential calculation and its impact on electron emission yields. The European Physical Journal Plus, 2021, 136 (3), pp.345. ⟨10.1140/epjp/s13360-021-01318-x⟩. ⟨hal-03186180⟩
- Anthime Flaus, Stéphane Nevesny, Jean-Baptiste Guy, Sandrine Sotton, Nicolas Magné, et al.. Positron emission tomography for radiotherapy planning in head and neck cancer: What impact?. Nucl.Med.Com., 2021, 42 (3), pp.234-243. ⟨10.1097/mnm.0000000000001329⟩. ⟨hal-03235662⟩
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