Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. The CMS trigger system. Journal of Instrumentation, 2017, 12 (01), pp.P01020. ⟨10.1088/1748-0221/12/01/P01020⟩. ⟨in2p3-01362517⟩
  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of inclusive jet cross-sections in pp and PbPb collisions at sqrt(s[NN])=2.76 TeV. Physical Review C, 2017, 96, pp.015202. ⟨10.1103/PhysRevC.96.015202⟩. ⟨in2p3-01368772⟩
  • A.M. Sirunyan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurements of the charm jet cross section and nuclear modification factor in pPb collisions at sqrt(s[NN]) = 5.02 TeV. Physics Letters B, 2017, 772, pp.306-329. ⟨10.1016/j.physletb.2017.06.053⟩. ⟨in2p3-01424868⟩
  • A.M. Sirunyan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for dark matter and unparticles in events with a Z boson and missing transverse momentum in proton-proton collisions at sqrt(s) = 13 TeV. Journal of High Energy Physics, 2017, 03(2017) (3), pp.061. ⟨10.1007/JHEP03(2017)061⟩. ⟨in2p3-01430542⟩
  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for R-parity violating supersymmetry with displaced vertices in proton-proton collisions at sqrt(s)=8 TeV. Physical Review D, 2017, 95, pp. 012009 ⟨10.1103/PhysRevD.95.012009⟩. ⟨in2p3-01383032⟩
  • A.M. Sirunyan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for massive resonances decaying into WW, WZ or ZZ bosons in proton-proton collisions at sqrt(s) = 13 TeV. Journal of High Energy Physics, 2017, 03 (3), pp.162. ⟨10.1007/JHEP03(2017)162⟩. ⟨in2p3-01424867⟩
  • Z. Deng, Y. Li, Y. Wang, Q. Yue, Z. Yang, et al.. Tracking within Hadronic Showers in the CALICE SDHCAL prototype using a Hough Transform Technique. Journal of Instrumentation, 2017, 12 (05), pp.P05009. ⟨10.1088/1748-0221/12/05/P05009⟩. ⟨hal-02066606⟩
  • Micaela Cunha, Etienne Testa, Michael Beuve, Jacques Balosso, Abdulhamid Chaikh. Considerations on the miniaturization of detectors for in vivo dosimetry in radiotherapy: A Monte Carlo study. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2017, 399, pp.20-27. ⟨10.1016/j.nimb.2017.03.078⟩. ⟨hal-01582804⟩
  • S. Pandeti, L. Feketeová, T.J. Reddy, H. Abdoul-Carime, B. Farizon, et al.. Nitroimidazolic radiosensitizers investigated by electrospray ionization time-of-flight mass spectrometry and density functional theory. RSC Advances, 2017, 7 (71), pp.45211-45221. ⟨10.1039/C7RA08312B⟩. ⟨hal-01719455⟩
  • Helene M. Courtois, R. Brent Tully, Yehuda Hoffman, Daniel Pomarede, Romain Graziani, et al.. Cosmicflows-3: Cold Spot Repeller?. The Astrophysical Journal Letters, 2017, 847 (1), pp.L6. ⟨10.3847/2041-8213/aa88b2⟩. ⟨hal-01645931⟩

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