Health (PRISME)

  • Presentation
  • Activities
  • Members
  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8787 documents

  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for supersymmetry in events with at least one photon, missing transverse momentum, and large transverse event activity in proton-proton collisions at \sqrt{s}=13 TeV. Journal of High Energy Physics, 2017, 12, pp.142. ⟨10.1007/JHEP12(2017)142⟩. ⟨hal-01704941⟩
  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Charged-particle nuclear modification factors in PbPb and pPb collisions at sqrt(s[NN)]=5.02 TeV. Journal of High Energy Physics, 2017, 04 (4), pp.039. ⟨10.1007/JHEP04(2017)039⟩. ⟨in2p3-01393699⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for new phenomena with the M_{\mathrm {T2}} variable in the all-hadronic final state produced in proton–proton collisions at \sqrt{s} = 13 \,\text {TeV}. Eur.Phys.J.C, 2017, 77 (10), pp.710. ⟨10.1140/epjc/s10052-017-5267-x⟩. ⟨hal-01669595⟩
  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for top squark pair production in compressed-mass-spectrum scenarios in proton-proton collisions at sqrt(s) = 8 TeV using the alphaT variable. Physics Letters B, 2017, 767, pp.403-430. ⟨10.1016/j.physletb.2017.02.007⟩. ⟨in2p3-01323688⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Ece Asilar, Thomas Bergauer, et al.. Combination of searches for heavy resonances decaying to WW, WZ, ZZ, WH, and ZH boson pairs in proton–proton collisions at \sqrt{s}=8 and 13 TeV. Physics Letters B, 2017, 774, pp.533-558. ⟨10.1016/j.physletb.2017.09.083⟩. ⟨hal-01669473⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Measurements of properties of the Higgs boson decaying into the four-lepton final state in pp collisions at \sqrt{s}=13 TeV. Journal of High Energy Physics, 2017, 11, pp.047. ⟨10.1007/JHEP11(2017)047⟩. ⟨hal-01669811⟩
  • A.M. Sirunyan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of the ttbar production cross section using events with one lepton and at least one jet in pp collisions at sqrt(s)=13 TeV. Journal of High Energy Physics, 2017, 09(2017) (9), pp.051. ⟨10.1007/JHEP09(2017)051⟩. ⟨in2p3-01449500⟩
  • A.M. Sirunyan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for associated production of a Z boson with a single top quark and for tZ flavour-changing interactions in pp collisions at sqrt(s) = 8 TeV. Journal of High Energy Physics, 2017, 07(2017) (7), pp.003. ⟨10.1007/JHEP07(2017)003⟩. ⟨in2p3-01458780⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Ece Asilar, Thomas Bergauer, et al.. Search for new physics in the monophoton final state in proton-proton collisions at \sqrt{s}=13 TeV. Journal of High Energy Physics, 2017, 10, pp.073. ⟨10.1007/JHEP10(2017)073⟩. ⟨hal-01669676⟩
  • A.M. Sirunyan, Armen Tumasyan, Wolfgang Adam, Ece Asilar, Thomas Bergauer, et al.. Particle-flow reconstruction and global event description with the CMS detector. JINST, 2017, 12 (10), pp.P10003. ⟨10.1088/1748-0221/12/10/P10003⟩. ⟨hal-01669711⟩

Powered by HAL logo