Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • S. Aghion, C. Amsler, T. Ariga, G. Bonomi, R.S. Brusa, et al.. Characterization of a transmission positron/positronium converter for antihydrogen production. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2017, 407, pp.55-66. ⟨10.1016/j.nimb.2017.05.059⟩. ⟨hal-01554901⟩
    • A. Vogt, B. Birkenbach, P. Reiter, A. Blazhev, M. Siciliano, et al.. Isomers and high-spin structures in the N=81 isotones ^{135}Xe and ^{137}Ba. Physical Review C, 2017, 95 (2), pp.024316. ⟨10.1103/PhysRevC.95.024316⟩. ⟨hal-01555125⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Observation of top quark production in proton-nucleus collisions. Phys.Rev.Lett., 2017, 119 (24), pp.242001. ⟨10.1103/PhysRevLett.119.242001⟩. ⟨hal-01669566⟩
    • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurements of the t-tbar production cross section in lepton+jets final states in pp collisions at 8 TeV and ratio of 8 to 7 TeV cross sections. European Physical Journal C: Particles and Fields, 2017, 77, pp.15. ⟨10.1140/epjc/s10052-016-4504-z⟩. ⟨in2p3-01280700⟩
    • A.M. Sirunyan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for single production of vector-like quarks decaying to a Z boson and a top or a bottom quark in proton-proton collisions at sqrt(s) = 13 TeV. Journal of High Energy Physics, 2017, 05, pp.029. ⟨10.1007/JHEP05(2017)029⟩. ⟨in2p3-01449422⟩
    • A.M. Sirunyan, Armen Tumasyan, Wolfgang Adam, Ece Aşılar, Thomas Bergauer, et al.. Measurements of the pp \to W\gamma\gamma and pp \to Z\gamma\gamma cross sections and limits on anomalous quartic gauge couplings at \sqrt{s}=8 TeV. JHEP, 2017, 10, pp.072. ⟨10.1007/JHEP10(2017)072⟩. ⟨hal-01669492⟩
    • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Observation of the decay B+ to psi(2S) phi K+ in pp collisions at sqrt(s) = 8 TeV. Physics Letters B, 2017, 764, pp.66-86. ⟨10.1016/j.physletb.2016.11.001⟩. ⟨in2p3-01344460⟩
    • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Inclusive search for supersymmetry using razor variables in pp collisions at sqrt(s) = 13 TeV. Physical Review D, 2017, 95, pp.012003. ⟨10.1103/PhysRevD.95.012003⟩. ⟨in2p3-01372217⟩
    • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of the WZ production cross section in pp collisions at sqrt{s} = 7 and 8 TeV and search for anomalous triple gauge couplings at sqrt{s} = 8 TeV. European Physical Journal C: Particles and Fields, 2017, 77, pp.236. ⟨10.1140/epjc/s10052-017-4730-z⟩. ⟨in2p3-01368774⟩
    • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for supersymmetry in events with photons and missing transverse energy in pp collisions at 13 TeV. Physics Letters B, 2017, 769, pp.391. ⟨10.1016/j.physletb.2017.04.005⟩. ⟨in2p3-01400604⟩

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