Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • I. Tomalin, L.E. Ardila-Perez, F.A. Ball, M.N. Balzer, G. Boudoul, et al.. An FPGA based track finder for the L1 trigger of the CMS experiment at the High Luminosity LHC. Journal of Instrumentation, 2017, 12, pp.P12019. ⟨10.1088/1748-0221/12/12/P12019⟩. ⟨hal-01703549⟩
  • A. Idini, K. Bennaceur, J. Dobaczewski. Landau parameters for energy density functionals generated by local finite-range pseudopotentials. Journal of Physics G: Nuclear and Particle Physics, 2017, 44, pp.064004. ⟨10.1088/1361-6471/aa691e⟩. ⟨in2p3-01420762⟩
  • J.-M. Richard, C. Fayard. Level rearrangement in three-body systems. Physics Letters A, 2017, 381, pp.3217-3221. ⟨10.1016/j.physleta.2017.08.021⟩. ⟨in2p3-01374204⟩
  • Ko Abe, Josh Amey, Costas Andreopoulos, Maria Antonova, Shigeki Aoki, et al.. Search for Lorentz and CPT violation using sidereal time dependence of neutrino flavor transitions over a short baseline. Physical Review D, 2017, 95 (11), pp.111101. ⟨10.1103/PhysRevD.95.111101⟩. ⟨hal-01582716⟩
  • A.M. Sirunyan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of the ttbar production cross section using events with one lepton and at least one jet in pp collisions at sqrt(s)=13 TeV. Journal of High Energy Physics, 2017, 09(2017) (9), pp.051. ⟨10.1007/JHEP09(2017)051⟩. ⟨in2p3-01449500⟩
  • A.M. Sirunyan, Armen Tumasyan, Wolfgang Adam, Ece Asilar, Thomas Bergauer, et al.. Particle-flow reconstruction and global event description with the CMS detector. Journal of Instrumentation, 2017, 12 (10), pp.P10003. ⟨10.1088/1748-0221/12/10/P10003⟩. ⟨hal-01669711⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for new phenomena with the M_{\mathrm {T2}} variable in the all-hadronic final state produced in proton–proton collisions at \sqrt{s} = 13 \,\text {TeV}. Eur.Phys.J.C, 2017, 77 (10), pp.710. ⟨10.1140/epjc/s10052-017-5267-x⟩. ⟨hal-01669595⟩
  • A.M. Sirunyan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for associated production of a Z boson with a single top quark and for tZ flavour-changing interactions in pp collisions at sqrt(s) = 8 TeV. Journal of High Energy Physics, 2017, 07(2017) (7), pp.003. ⟨10.1007/JHEP07(2017)003⟩. ⟨in2p3-01458780⟩
  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Observation of Upsilon(1S) pair production in proton-proton collisions at sqrt(s) = 8 TeV. Journal of High Energy Physics, 2017, 05, pp.013. ⟨10.1007/JHEP05(2017)013⟩. ⟨in2p3-01387006⟩
  • Jaroslav Adam, Dagmar Adamova, Madan Mohan Aggarwal, Gianluca Aglieri Rinella, Michelangelo Agnello, et al.. Enhanced production of multi-strange hadrons in high-multiplicity proton-proton collisions. Nature Physics, 2017, 13, pp.535-539. ⟨10.1038/nphys4111⟩. ⟨hal-01703781⟩

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