Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8787 documents

  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for electroweak production of charginos and neutralinos in WH events in proton-proton collisions at \sqrt{s}=13 TeV. Journal of High Energy Physics, 2017, 11, pp.029. ⟨10.1007/JHEP11(2017)029⟩. ⟨hal-01669808⟩
  • A.M. Sirunyan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of the inclusive energy spectrum in the very forward direction in proton-proton collisions at sqrt(s)=13 TeV. Journal of High Energy Physics, 2017, 08 (8), pp.046. ⟨10.1007/JHEP08(2017)046⟩. ⟨in2p3-01450075⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Ece Aşılar, Thomas Bergauer, et al.. Measurement of double-differential cross sections for top quark pair production in pp collisions at \sqrt{s} = 8 \,\text {TeV} and impact on parton distribution functions. Eur.Phys.J.C, 2017, 77 (7), pp.459. ⟨10.1140/epjc/s10052-017-4984-5⟩. ⟨hal-01669618⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Ece Aşılar, Thomas Bergauer, et al.. Measurement of the top quark mass using single top quark events in proton-proton collisions at \sqrt{s}= 8 TeV. Eur.Phys.J.C, 2017, 77 (5), pp.354. ⟨10.1140/epjc/s10052-017-4912-8⟩. ⟨hal-01669636⟩
  • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Evidence for collectivity in pp collisions at the LHC. Physics Letters B, 2017, 765, pp.193-220. ⟨10.1016/j.physletb.2016.12.009⟩. ⟨in2p3-01334567⟩
  • V. Khachatryan, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, et al.. Coherent J/Psi photoproduction in ultra-peripheral PbPb collisions at sqrt(s[NN]) = 2.76 TeV with the CMS experiment. Physics Letters B, 2017, 772, pp.489. ⟨10.1016/j.physletb.2017.07.001⟩. ⟨in2p3-01320612⟩
  • A.M. Sirunyan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Azimuthal anisotropy of charged particles with transverse momentum up to 100 GeV in PbPb collisions at sqrt(s[NN]) = 5.02 TeV. Physics Letters B, 2017, 776, pp.195. ⟨10.1016/j.physletb.2017.11.041⟩. ⟨in2p3-01454724⟩
  • A.M. Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for a light pseudoscalar Higgs boson produced in association with bottom quarks in pp collisions at \sqrt{s}=8 TeV. Journal of High Energy Physics, 2017, 11, pp.010. ⟨10.1007/JHEP11(2017)010⟩. ⟨hal-01669855⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Ece Asilar, Thomas Bergauer, et al.. Measurement of the semileptonic \mathrm{t}\overline{\mathrm{t}} + γ production cross section in pp collisions at \sqrt{s}=8 TeV. Journal of High Energy Physics, 2017, 10, pp.006. ⟨10.1007/JHEP10(2017)006⟩. ⟨hal-01669654⟩
  • A.M. Sirunyan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Relative modification of prompt psi(2S) and J/psi yields from pp to PbPb collisions at sqrt(s[NN]) = 5.02 TeV. Physical Review Letters, 2017, 118, pp.162301. ⟨10.1103/PhysRevLett.118.162301⟩. ⟨in2p3-01393196⟩

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