Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for Evidence of the Type-III Seesaw Mechanism in Multilepton Final States in Proton-Proton Collisions at \sqrt{s}=13\text{ }\text{ }\mathrm{TeV}. Phys.Rev.Lett., 2017, 119 (22), pp.221802. ⟨10.1103/PhysRevLett.119.221802⟩. ⟨hal-01669772⟩
    • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of inclusive jet cross-sections in pp and PbPb collisions at sqrt(s[NN])=2.76 TeV. Physical Review C, 2017, 96, pp.015202. ⟨10.1103/PhysRevC.96.015202⟩. ⟨in2p3-01368772⟩
    • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for high-mass diphoton resonances in proton-proton collisions at 13 TeV and combination with 8 TeV search. Physics Letters B, 2017, 767, pp.147-170. ⟨10.1016/j.physletb.2017.01.027⟩. ⟨in2p3-01362519⟩
    • S. Chatrchyan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurement of the mass difference between top quark and antiquark in pp collisions at sqrt(s) = 8 TeV. Physics Letters B, 2017, 770, pp.50. ⟨10.1016/j.physletb.2017.04.028⟩. ⟨in2p3-01391396⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Ece Asilar, Thomas Bergauer, et al.. Search for Higgs boson pair production in the bb\tau\tau final state in proton-proton collisions at \sqrt{(}s)=8\text{ }\text{ }\mathrm{TeV}. Phys.Rev.D, 2017, 96 (7), pp.072004. ⟨10.1103/PhysRevD.96.072004⟩. ⟨hal-01669749⟩
    • V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for R-parity violating supersymmetry with displaced vertices in proton-proton collisions at sqrt(s)=8 TeV. Physical Review D, 2017, 95, pp. 012009 ⟨10.1103/PhysRevD.95.012009⟩. ⟨in2p3-01383032⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for supersymmetry in multijet events with missing transverse momentum in proton-proton collisions at 13 TeV. Phys.Rev.D, 2017, 96 (3), pp.032003. ⟨10.1103/PhysRevD.96.032003⟩. ⟨hal-01669444⟩
    • A.M. Sirunyan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Measurements of the charm jet cross section and nuclear modification factor in pPb collisions at sqrt(s[NN]) = 5.02 TeV. Physics Letters B, 2017, 772, pp.306-329. ⟨10.1016/j.physletb.2017.06.053⟩. ⟨in2p3-01424868⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for top squark pair production in pp collisions at \sqrt{s}=13 TeV using single lepton events. JHEP, 2017, 10, pp.019. ⟨10.1007/JHEP10(2017)019⟩. ⟨hal-01669801⟩
    • Giacomo Cacciapaglia, Haiying Cai, Alexandra Carvalho, Aldo Deandrea, Thomas Flacke, et al.. Probing vector-like quark models with Higgs-boson pair production. Journal of High Energy Physics, 2017, 07, pp.005. ⟨10.1007/JHEP07(2017)005⟩. ⟨hal-01582426⟩

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