Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • A.M. Sirunyan, Armen Tumasyan, Wolfgang Adam, Ece Asilar, Thomas Bergauer, et al.. Search for dark matter produced in association with heavy-flavor quark pairs in proton-proton collisions at \sqrt{s}=13 TeV. Eur.Phys.J.C, 2017, 77 (12), pp.845. ⟨10.1140/epjc/s10052-017-5317-4⟩. ⟨hal-01669494⟩
  • J.R. Batley, G. Kalmus, C. Lazzeroni, D.J. Munday, M.W. Slater, et al.. Searches for lepton number violation and resonances in K^{\pm}\to\pi\mu\mu decays. Phys.Lett.B, 2017, 769, pp.67-76. ⟨10.1016/j.physletb.2017.03.029⟩. ⟨hal-01582712⟩
  • J. Adam, B. Audurier, A. Baldisseri, Guillaume Batigne, J. Castillo Castellanos, et al.. Anomalous broadening of the near-side jet peak in Pb-Pb collisions at \sqrt{s_{\rm{NN}}} = 2.76 TeV. Physical Review Letters, 2017, 119, pp.102301 ⟨10.1103/PhysRevLett.119.102301⟩. ⟨in2p3-01370108⟩
  • Shreyasi Acharya, Jaroslav Adam, Dagmar Adamova, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. Kaon femtoscopy in Pb-Pb collisions at \sqrt{s_{\rm{NN}}} = 2.76 TeV. Physical Review C, 2017, 96 (6), pp.064613. ⟨10.1103/PhysRevC.96.064613⟩. ⟨hal-01703863⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for heavy resonances that decay into a vector boson and a Higgs boson in hadronic final states at \sqrt{s} = 13 \,\text {TeV}. Eur.Phys.J.C, 2017, 77 (9), pp.636. ⟨10.1140/epjc/s10052-017-5192-z⟩. ⟨hal-01669447⟩
  • K. Bennaceur, A. Idini, J. Dobaczewski, P. Dobaczewski, M. Kortelainen, et al.. Nonlocal energy density functionals for pairing and beyond-mean-field calculations. Journal of Physics G: Nuclear and Particle Physics, 2017, 44, pp.045106. ⟨10.1088/1361-6471/aa5fd7⟩. ⟨in2p3-01406293⟩
  • Yongcheng Wu, Teng Ma, Bin Zhang, Giacomo Cacciapaglia. Composite Dark Matter and Higgs. Journal of High Energy Physics, 2017, 11, pp.058. ⟨10.1007/JHEP11(2017)058⟩. ⟨hal-01669529⟩
  • Wook-Geun Shin, Mauro Testa, Hak Soo Kim, Jong Hwi Jeong, Se Byeong Lee, et al.. Independent dose verification system with Monte Carlo simulations using TOPAS for passive scattering proton therapy at the National Cancer Center in Korea. Physics in Medicine and Biology, 2017, 62 (19), pp.7598-7616. ⟨10.1088/1361-6560/aa8663⟩. ⟨hal-01763848⟩
  • J. Krimmer, G. Angellier, L. Balleyguier, D. Dauvergne, N. Freud, et al.. A cost-effective monitoring technique in particle therapy via uncollimated prompt gamma peak integration. Applied Physics Letters, 2017, 110 (15), pp.154102. ⟨10.1063/1.4980103⟩. ⟨hal-01508408⟩
  • Benoîte Méry, Jean-Baptiste Guy, Alexis Vallard, Sophie Espenel, Dominique Ardail, et al.. In Vitro Cell Death Determination for Drug Discovery: A Landscape Review of Real Issues. Journal of Cell Death, 2017, 10, ⟨10.1177/1179670717691251⟩. ⟨hal-01610108⟩

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