Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8787 documents

  • Vincenzo Cirigliano, Sacha Davidson, Yoshitaka Kuno. Spin-dependent \mu \to e conversion. Physics Letters B, 2017, 771, pp.242-246. ⟨10.1016/j.physletb.2017.05.053⟩. ⟨hal-01554923⟩
  • A. Vogt, B. Birkenbach, P. Reiter, A. Blazhev, M. Siciliano, et al.. Isomers and high-spin structures in the N=81 isotones ^{135}Xe and ^{137}Ba. Physical Review C, 2017, 95 (2), pp.024316. ⟨10.1103/PhysRevC.95.024316⟩. ⟨hal-01555125⟩
  • P. Lansonneur, P. Bräunig, A. Demetrio, S.R. Müller, P. Nedelec, et al.. Probing electric and magnetic fields with a Moiré deflectometer. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2017, 862, pp.49-53. ⟨10.1016/j.nima.2017.04.041⟩. ⟨hal-01582805⟩
  • Daniel Pomarede, Helene M. Courtois, Yehuda Hoffman, R. Brent Tully. Cosmography and Data Visualization. Publications of the Astronomical Society of the Pacific, 2017, 129 (975), pp.058002. ⟨10.1088/1538-3873/aa5b73⟩. ⟨in2p3-01468464⟩
  • X. Huang, Z. Raha, G. Aldering, P. Antilogus, S. Bailey, et al.. The Extinction Properties of and Distance to the Highly Reddened Type Ia Supernova SN 2012cu. The Astrophysical Journal, 2017, 836, pp.157. ⟨10.3847/1538-4357/836/2/157⟩. ⟨in2p3-01430546⟩
  • C. Monini, É. Testa, M. Beuve. NanOx Predictions of Cell Survival Probabilities for Three Cell Lines. Acta Phys.Polon.B, 2017, 48 (10), pp.1653. ⟨10.5506/APhysPolB.48.1653⟩. ⟨hal-01719459⟩
  • A. Korichi, T. Lauritsen, A.N. Wilson, J. Dudouet, E. Clément, et al.. Performance of a gamma-ray tracking array: Characterizing the AGATA array using a 60Co source. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2017, 872, pp.60039. ⟨10.1016/j.nima.2017.08.020⟩. ⟨hal-01645783⟩
  • S. Acharya, A. Baldisseri, H. Borel, J. Castillo Castellanos, J.L. Charvet, et al.. Production of \pi^0 and \eta mesons up to high transverse momentum in pp collisions at 2.76 TeV. European Physical Journal C: Particles and Fields, 2017, 77, pp.339. ⟨10.1140/epjc/s10052-017-4890-x⟩. ⟨in2p3-01456786⟩
  • J. Adam, Laurent Aphecetche, B. Audurier, A. Baldisseri, Guillaume Batigne, et al.. Measurement of electrons from beauty-hadron decays in p-Pb collisions at \mathbf{\sqrt{s_{\rm NN}}=5.02} TeV and Pb-Pb collisions at \mathbf{\sqrt{s_{\rm NN}}=2.76} TeV. Journal of High Energy Physics, 2017, 07 (7), pp.052. ⟨10.1007/JHEP07(2017)052⟩. ⟨in2p3-01366031⟩
  • Shreyasi Acharya, Dagmar Adamova, Jonatan Adolfsson, Madan Mohan Aggarwal, Gianluca Aglieri Rinella, et al.. J/\psi elliptic flow in Pb-Pb collisions at \sqrt{s_\mathrm{NN}}=5.02 TeV. Physical Review Letters, 2017, 119 (24), pp.242301. ⟨10.1103/PhysRevLett.119.242301⟩. ⟨hal-01669832⟩

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