Health

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:

SAADE Gaëlle

8786 documents

Y. Hoffman, D. Pomarède, R. Brent Tully, H. Courtois. The Dipole Repeller. Nature Astronomy, 2017, 1 (2), pp.36. ⟨10.1038/s41550-016-0036⟩. ⟨in2p3-01468457⟩
V.M. Abazov, M.-C. Cousinou, A. Duperrin, W. Geng, E. Kajfasz, et al.. Measurement of the direct CP violating charge asymmetry in $B^\pm \rightarrow \mu^\pm \nu_\mu D^{0}$ decays. Physical Review D, 2017, 95, pp.031101(R) ⟨10.1103/PhysRevD.95.031101⟩. ⟨in2p3-01351230⟩
M. Klintefjord, J. Ljungvall, A. Görgen, M. Lenzi, F. Bello Garrote, et al.. Measurement of lifetimes in $^{62,64}$ Fe, $^{61,63}$ Co, and $^{59}$ Mn. Physical Review C, 2017, 95 (2), pp.024312. ⟨10.1103/PhysRevC.95.024312⟩. ⟨in2p3-01468946⟩
Mohammed Omer Khojali, A.S. Cornell, Aldo Deandrea, Giacomo Cacciapaglia. Evolution of the gauge couplings and Weinberg angle in 5-dimensions for a G $_2$ gauge group. Workshop on High Energy Particle Physics, Feb 2017, Johannesburg, South Africa. pp.012012, ⟨10.1088/1742-6596/889/1/012012⟩. ⟨hal-02058587⟩
J. Adam, Laurent Aphecetche, B. Audurier, A. Baldisseri, Guillaume Batigne, et al.. J/ $\psi$ suppression at forward rapidity in Pb-Pb collisions at $\mathbf{\sqrt{s_{{\rm NN}}} = 5.02}$ TeV. Physics Letters B, 2017, 766, pp.212-224. ⟨10.1016/j.physletb.2016.12.064⟩. ⟨in2p3-01338145⟩
S. Acharya, Laurent Aphecetche, B. Audurier, A. Baldisseri, Guillaume Batigne, et al.. Production of muons from heavy-flavour hadron decays in p-Pb collisions at $\mathbf{\sqrt{{\textit s}_{NN}} = 5.02}$ TeV. Physics Letters B, 2017, 770, pp.459-472. ⟨10.1016/j.physletb.2017.03.049⟩. ⟨in2p3-01458784⟩
V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for supersymmetry in the all-hadronic final state using top quark tagging in pp collisions at sqrt(s) = 13 TeV. Physical Review D, 2017, 96, pp.012004. ⟨10.1103/PhysRevD.96.012004⟩. ⟨in2p3-01430537⟩
V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for single production of a heavy vector-like T quark decaying to a Higgs boson and a top quark with a lepton and jets in the final state. Physics Letters B, 2017, 771, pp.80-105. ⟨10.1016/j.physletb.2017.05.019⟩. ⟨in2p3-01409593⟩
V. Khachatryan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Search for electroweak production of charginos in final states with two tau leptons in pp collisions at sqrt(s) = 8 TeV. Journal of High Energy Physics, 2017, 04 (4), pp.018. ⟨10.1007/JHEP04(2017)018⟩. ⟨in2p3-01383031⟩
A.M. Sirunyan, M. Besançon, F. Couderc, M. Dejardin, D. Denegri, et al.. Cross section measurement of t-channel single top quark production in pp collisions at sqrt(s) = 13 TeV. Physics Letters B, 2017, 72, pp.752. ⟨10.1016/j.physletb.2017.07.047⟩. ⟨in2p3-01376035⟩

Health (PRISME)

Contact

Domains

Keywords

Authors

Affiliated authors

Journals

Year of production

Institutions

Laboratories

Departments

Research team