Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:
    8790 documents

    • Anne-Sophie Wozny, Jean-Baptiste Guy, CĂ©line MalĂ©sys, Priscillia Battiston-Montagne, Michael Beuve, et al.. Role of HIF-1α in the Resistance of Cancer Stem Cells to Photon and Carbon Ion Irradiations. Forum de la Recherche en CancĂ©rologie Auvergne-RhĂ´ne-Alpes 2017, Apr 2017, Lyon, France. ⟨hal-01504697⟩
    • M. Vignetti, F. Calmon, P. Pittet, G. Pares, R. Cellier, et al.. 3D Silicon Coincidence Avalanche Detector (3D-SiCAD) for Hadrontherapy and Proton Tomography : Preliminary Results on Charged Particle Detection. Forum de la Recherche en CancĂ©rologie Auvergne-RhĂ´ne-Alpes 2017, Apr 2017, Lyon, France. ⟨hal-01504838⟩
    • Caterina Monini, Michael Beuve, Etienne Testa, Micaela Cunha. NanOxTM, a New Multiscale Model to Predict Ion RBE in Hadrontherapy. Forum de la Recherche en CancĂ©rologie Auvergne-RhĂ´ne-Alpes 2017, Apr 2017, Lyon, France. ⟨hal-01504798⟩
    • Jean-Baptiste Guy, Sophie Espenel, Anne-Sophie Wozny, Priscillia Battiston-Montagne, ChloĂ© Rancoule, et al.. Ciblage des cellules souches cancĂ©reuses dans les cancers ORL : effet synergique de l’ABT-199 et du cetuximab en association Ă  la radiothĂ©rapie photonique. Forum de la Recherche en CancĂ©rologie Auvergne-RhĂ´ne-Alpes 2017, Apr 2017, Lyon, France. ⟨hal-01504662⟩
    • J. Dudouet, A. Lemasson, G. DuchĂŞne, M. Rejmund, E. ClĂ©ment, et al.. ^{96}_{36}Kr_{60}–Low-Z Boundary of the Island of Deformation at N =60. Physical Review Letters, 2017, 118, pp.165201. ⟨10.1103/PhysRevLett.118.162501⟩. ⟨in2p3-01518704⟩
    • L. Sarrasin, N. Moncoffre, C. Gaillard, Y. Pipon, R. Ducher. MĂ©canismes d’incorporation et de migration du Mo dans le dioxyde d’uranium stĹ“chiomĂ©trique et sur-stĹ“chiomĂ©trique. JournĂ©es des thèses IRSN, Mar 2017, Carry le Rouet, France. ⟨in2p3-02097459⟩
    • L. Finco. H -> gg in CMS. 10th France China Particle Physics Laboratory workshop (FCPPL 2017), Mar 2017, Pekin, China. ⟨hal-02071506⟩
    • Etienne Testa. CONTROLE DE L’HADRONTHERAPIE PAR DETECTION DE RAYONNEMENTS SECONDAIRES. Recherche en Imagerie et Technologies pour la SantĂ© (RITS) 2017, Mar 2017, Lyon, France. ⟨hal-01504991⟩
    • Sijing Zhang. Low mass H-->gamma gamma in CMS. 10th France China Particle Physics Laboratory workshop (FCPPL 2017), Mar 2017, Beijing, China. ⟨hal-02071301⟩
    • Claire Rodriguez-Lafrasse. APPLICATIONS DES NANOPARTICULES METALLIQUES EN RADIOTHERAPIE ET EN IMAGERIE. Recherche en Imagerie et Technologies pour la SantĂ© (RITS) 2017, Mar 2017, Lyon, France. ⟨hal-01504999⟩

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