Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • Nils Krah, Denis Dauvergne, Jean Michel LĂ©tang, Simon Rit, Etienne Testa. Energy-adaptive calculation of the most likely path in proton CT. Physics in Medicine and Biology, 2021, 66, pp.20NT02. ⟨10.1088/1361-6560/ac2999⟩. ⟨hal-03353954⟩
    • Armen Tumasyan, Wolfgang Adam, Janik Walter Andrejkovic, Thomas Bergauer, Suman Chatterjee, et al.. Measurements of the pp \to W^\pm\gamma\gamma and pp \to Z\gamma\gamma cross sections at \sqrt{s} = 13 TeV and limits on anomalous quartic gauge couplings. JHEP, 2021, 10, pp.174. ⟨10.1007/JHEP10(2021)174⟩. ⟨hal-03261352⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Search for the lepton flavor violating decay \tau \to 3\mu in proton-proton collisions at \sqrt{s} = 13 TeV. JHEP, 2021, 01, pp.163. ⟨10.1007/JHEP01(2021)163⟩. ⟨hal-02939897⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. First measurement of large area jet transverse momentum spectra in heavy-ion collisions. JHEP, 2021, 05, pp.284. ⟨10.1007/JHEP05(2021)284⟩. ⟨hal-03171405⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Thomas Bergauer, Marko Dragicevic, et al.. Angular analysis of the decay B^+ \to K^*(892)^+\mu^+\mu^- in proton-proton collisions at \sqrt{s} = 8 TeV. JHEP, 2021, 04, pp.124. ⟨10.1007/JHEP04(2021)124⟩. ⟨hal-03022669⟩
    • Armen Tumasyan, Wolfgang Adam, Janik Walter Andrejkovic, Thomas Bergauer, Suman Chatterjee, et al.. Measurement of the electroweak production of Z\gamma and two jets in proton-proton collisions at \sqrt{s} = 13 TeV and constraints on anomalous quartic gauge couplings. Phys.Rev.D, 2021, 104, pp.072001. ⟨10.1103/PhysRevD.104.072001⟩. ⟨hal-03280754⟩
    • R. Abbott, T.D. Abbott, S. Abraham, F. Acernese, K. Ackley, et al.. Search for anisotropic gravitational-wave backgrounds using data from Advanced LIGO and Advanced Virgo’s first three observing runs. Phys.Rev.D, 2021, 104 (2), pp.022005. ⟨10.1103/PhysRevD.104.022005⟩. ⟨hal-03186190⟩
    • R. Abbott, T.D. Abbott, F. Acernese, K. Ackley, C. Adams, et al.. All-sky search for long-duration gravitational-wave bursts in the third Advanced LIGO and Advanced Virgo run. Phys.Rev.D, 2021, 104 (10), pp.102001. ⟨10.1103/PhysRevD.104.102001⟩. ⟨hal-03428826⟩
    • R. Abbott, T.D. Abbott, S. Abraham, F. Acernese, K. Ackley, et al.. GWTC-2: Compact Binary Coalescences Observed by LIGO and Virgo During the First Half of the Third Observing Run. Phys.Rev.X, 2021, 11 (2), pp.021053. ⟨10.1103/PhysRevX.11.021053⟩. ⟨hal-03022673⟩
    • R. Abbott, T.D. Abbott, S. Abraham, F. Acernese, K. Ackley, et al.. Upper limits on the isotropic gravitational-wave background from Advanced LIGO and Advanced Virgo’s third observing run. Phys.Rev.D, 2021, 104 (2), pp.022004. ⟨10.1103/PhysRevD.104.022004⟩. ⟨hal-03203682⟩

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