Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
476 documents

  • M. Fontana, J.-L. Ley, D. Dauvergne, Nicolas Freud, J. Krimmer, et al.. Monitoring ion beam therapy with a Compton Camera: simulation studies of the clinical feasibility. IEEE Transactions on Radiation and Plasma Medical Sciences, 2020, 4 (2), pp.218-232. ⟨10.1109/TRPMS.2019.2933985⟩. ⟨hal-02301075⟩
  • Christian Carrie, Nicolas Magné, Patricia Burban-Provost, Paul Sargos, Igor Latorzeff, et al.. Short-term androgen deprivation therapy combined with radiotherapy as salvage treatment after radical prostatectomy for prostate cancer (GETUG-AFU 16): a 112-month follow-up of a phase 3, randomised trial. Lancet Oncology, 2019, 20, pp.1740 - 1749. ⟨10.1016/S1470-2045(19)30486-3⟩. ⟨hal-03489049⟩
  • O. Allegrini, J. P. Cachemiche, C. Caplan, B. Carlus, X. Chen, et al.. Test and characterization of the CLaRyS camera's absorber with its final acquisition chain. Young Investigator's Workshop on Photon Detection in Medicine and Medical Physics - 2019, Dec 2019, Siegen, Germany. . ⟨hal-02408478⟩
  • X. Chen, O. Allegrini, B. Carlus, C. Caplan, L. Caponetto, et al.. A Time-Of-Flight Gamma Camera Data Acquisition System for Hadrontherapy Monitoring. NSS/MIC 2019 : IEEE Nuclear Science Symposium and Medical Imaging Conference, Oct 2019, Manchester, United Kingdom. pp.1-3, ⟨10.1109/NSS/MIC42101.2019.9060072⟩. ⟨hal-02309735⟩
  • C. Caplan, O. Allegrini, J. P. Cachemiche, B. Carlus, X. Chen, et al.. A μTCA back-end firmware for data acquisition and slow control of the CLaRyS Compton camera. NSS/MIC 2019 : IEEE Nuclear Science Symposium and Medical Imaging Conference, Oct 2019, Manchester, United Kingdom. ⟨10.1109/NSS/MIC42101.2019.9059941⟩. ⟨hal-02309672⟩
  • Ahmad Addoum, Nils Krah, Jean Michel Létang, Simon Rit. Proton scatter radiography with integration-mode detectors by exploiting the West-Sherwood effect. 2019 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), Oct 2019, Manchester, United Kingdom. ⟨hal-03126835⟩
  • J. Livingstone, A. Etxebeste, S. Curtoni, D. Dauvergne, M. Fontana, et al.. Ultra fast prompt-gamma imaging for the online monitoring of the ion range in hadron therapy. NSS/MIC 2019 : IEEE Nuclear Science Symposium and Medical Imaging Conference, Oct 2019, Manchester, United Kingdom. ⟨hal-02309773⟩
  • Nils Krah, Jean-Michel Létang, Simon Rit. Polynomial modelling of proton trajectories in homogeneous media for fast most likely path estimation and trajectory simulation. Physics in Medicine and Biology, 2019, 64 (19), pp.195014. ⟨10.1088/1361-6560/ab3d0b⟩. ⟨hal-02269520⟩
  • Caterina Monini, Gersende Alphonse, Claire Rodriguez-Lafrasse, Etienne Testa, Michael Beuve. Comparison of biophysical models with experimental data for three cell lines in response to irradiation with monoenergetic ions. Physics and Imaging in Radiation Oncology, 2019, 12, pp.17-21. ⟨10.1016/j.phro.2019.10.004⟩. ⟨hal-02543068⟩
  • Floriane Poignant. Physical, chemical and biological modelling for gold nanoparticle-enhanced radiation therapy : towards a better understanding and optimization of the radiosensitizing effect. Physics [physics]. Université de Lyon, 2019. English. ⟨NNT : 2019LYSE1160⟩. ⟨tel-03506229⟩

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