Health (PRISME)

  • Presentation
  • Activities
  • Members
  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • Christos Gentsos, Giacomo Fedi, Guido Magazzù, Daniel Magalotti, Atanu Modak, et al.. Track finding mezzanine for Level-1 triggering in HL-LHC experiments. 6th International Conference on Modern Circuits and Systems Technologies, May 2017, Thessaloniki, Greece. pp.7937676, ⟨10.1109/MOCAST.2017.7937676⟩. ⟨hal-01669641⟩
  • E. Armengaud, Q. Arnaud, C. Augier, A. Benoît, L. Bergé, et al.. Measurement of the cosmogenic activation of germanium detectors in EDELWEISS-III. Astroparticle Physics, 2017, 91, pp.51-64. ⟨10.1016/j.astropartphys.2017.03.006⟩. ⟨in2p3-01345962⟩
  • E. Clément, C. Michelagnoli, G. De France, H.J. Li, A. Lemasson, et al.. Conceptual design of the AGATA 1\pi array at GANIL. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2017, 855, pp.1-12. ⟨10.1016/j.nima.2017.02.063⟩. ⟨cea-01538475⟩
  • Anne-Sophie Wozny, Alexandra Lauret, Priscillia Battiston-Montagne, Jean-Baptiste Guy, Michael Beuve, et al.. Differential pattern of HIF-1α expression in HNSCC cancer stem cells after carbon ion or photon irradiation: one molecular explanation of the oxygen effect. British Journal of Cancer, 2017, 116 (10), pp.1340 - 1349. ⟨10.1038/bjc.2017.100⟩. ⟨cea-01938093⟩
  • Emilie Bernichon, Chloé Rancoule, Alexis Vallard, Julien Langrand-Escure, Benoîte Méry, et al.. Immunothérapie : après le focus sur les voies de signalisation, l’activation d’un système. Bulletin du Cancer, 2017, 104 (5), pp.462 - 475. ⟨10.1016/j.bulcan.2017.03.004⟩. ⟨hal-01610120⟩
  • J-L. Charvet, V.J.G. Feuillard, A. Rakotozafindrabe, J. Adam, Laurent Aphecetche, et al.. \phi-Meson production at forward rapidity in p-Pb collisions at \sqrt{S_{NN}}=5.02 TeV and in pp collisions at \sqrt{S}=2.76 TeV. Physics Letters B, 2017, 768, pp.203-217. ⟨10.1016/j.physletb.2017.01.074⟩. ⟨in2p3-01170083v2⟩
  • D. Autiero. ProtoDUNE dual−phase overview. Design Review of Dual−Phase Proto− DUNE, Apr 2017, Genève, Switzerland. ⟨in2p3-02108205⟩
  • D. Autiero. Charge readout FE electronics design. Design Review of Dual−Phase Proto− DUNE, Apr 2017, Genève, Switzerland. ⟨in2p3-02108207⟩
  • Davide Caiulo. Charge readout analysis in Liquid Argon Time Projection Chambers for neutrino and astro-particle physics. Atomic Physics [physics.atom-ph]. Université de Lyon, 2017. English. ⟨NNT : 2017LYSE1065⟩. ⟨tel-01578565⟩
  • D. Autiero. WP8/NA7 Large scale cryogenic liquid detectors. AIDA 2020 mid−term review, Apr 2017, Genève, Switzerland. ⟨in2p3-02108202⟩

Powered by HAL logo